ArticleSensors and actuators. B, Chemical2012
Transitioning Streaming to Trapping in DC Insulator-based Dielectrophoresis for Biomolecules.
Article in Sensors and actuators. B, Chemical, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- High-resolution 3D-printed insulator-based dielectrophoresis devices for biomolecular manipulation.Analytical and bioanalytical chemistry · 2026Article
- Protein Manipulation via Dielectrophoresis: Theoretical Principles and Emerging Microfluidic Platforms.Micromachines · 2025Review
- Visual and Quantitative Analysis of the Trapping Volume in Dielectrophoresis of Nanoparticles.Nano letters · 2024Article
- Numerical modeling reveals improved organelle separation for dielectrophoretic ratchet migration.Electrophoresis · 2023Article
- Protein Dielectrophoresis with Gradient Array of Conductive Electrodes Sheds New Light on Empirical Theory.Analytical chemistry · 2023Article
- Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?Biosensors · 2022Review
- Hybridization-based DNA biosensing with a limit of detection of 4 fM in 30 s using an electrohydrodynamic concentration module fabricated by grayscale lithography.Biomicrofluidics · 2022Article
- Continuous organelle separation in an insulator-based dielectrophoretic device.Electrophoresis · 2022Article
- Protein Dielectrophoresis: A Tale of Two Clausius-Mossottis-Or Something Else?Micromachines · 2022Article
- Charge-Based Separation of Micro- and Nanoparticles.Micromachines · 2020Article
- Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications.Sensors (Basel, Switzerland) · 2020Review
- Dielectrophoresis of proteins: experimental data and evolving theory.Analytical and bioanalytical chemistry · 2020Article
- Protein Dielectrophoresis: I. Status of Experiments and an Empirical Theory.Micromachines · 2020Article
- Electrokinetic characterization of synthetic protein nanoparticles.Beilstein journal of nanotechnology · 2020Article
- Low frequency cyclical potentials for fine tuning insulator-based dielectrophoretic separations.Biomicrofluidics · 2019Article
- A mathematical model of dielectrophoretic data to connect measurements with cell properties.Analytical and bioanalytical chemistry · 2019Article
- Deterministic Absolute Negative Mobility for Micro- and Submicrometer Particles Induced in a Microfluidic Device.Analytical chemistry · 2016Article
- Article
- Protein dielectrophoresis and the link to dielectric properties.Bioanalysis · 2015Review
- Temporal and spatial temperature measurement in insulator-based dielectrophoretic devices.Analytical chemistry · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Exploiting dielectrophoresis (DEP) to concentrate and separate biomolecules has recently shown large potential as a microscale bioanalytical tool. Such efforts however require tailored devices and knowledge of all interplaying transport mechanisms competing with dielectrophoresis (DEP). Specifically, a strong DEP contribution to the overall transport mechanism is necessary to exploit DEP of biomolecules for analytical applications such as separation and fractionation. Here, we present improved microfluidic devices combining optical lithography and focused ion beam milling (FIBM) for the manipulation of DNA and proteins using insulator-based dielectrophoresis (iDEP) and direct current (DC) electric fields. Experiments were performed on an elastomer platform forming the iDEP microfluidic device with integrated nanoposts and nanopost arrays. Microscale and nanoscale iDEP was studied for λ-DNA (48.5 kbp) and the protein bovine serum albumin (BSA). Numerical simulations were adapted to the various tested geometries revealing excellent qualitative agreement with experimental observations for streaming and trapping DEP. Both the experimental and simulation results indicate that DC iDEP trapping for λ-DNA occurs with tailored nanoposts fabricated via FIBM. Moreover, streaming iDEP concentration of BSA is improved with integrated nanopost arrays by a factor of 45 compared to microfabricated arrays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.