ArticleJournal of magnetic resonance imaging : JMRI2013
Stimulated echo diffusion tensor imaging and SPAIR T2 -weighted imaging in chronic exertional compartment syndrome of the lower leg muscles.
Article in Journal of magnetic resonance imaging : JMRI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Systematic Review of Innovative Diagnostic Tests for Chronic Exertional Compartment Syndrome.International journal of sports medicine · 2023Pooled it
- Time-dependent diffusion in skeletal muscle with the random permeable barrier model (RPBM): application to normal controls and chronic exertional compartment syndrome patients.NMR in biomedicine · 2014Trial
- Imaging characterization and differential diagnosis of delayed-onset muscle soreness (DOMS) in athletes.Skeletal radiology · 2026Review
- Muscle Imaging Assessments in Sarcopenia: A Statement from China National Center for Orthopedics (NCO) and the East Meets West Action Group of the European Calcified Tissue Society (ECTS).Calcified tissue international · 2025Review
- Stimulated echo acquisition mode (STEAM) diffusion tensor imaging with different diffusion encoding times in the supraspinatus muscle: Test-retest reliability and comparison to spin echo diffusion tensor imaging.NMR in biomedicine · 2025Article
- Multi-parametric quantitative MRI of the lower limb muscles in a longitudinal study of limb-girdle muscular dystrophy R9.PloS one · 2025Article
- Investigating skeletal muscle micro-trauma with time-dependent diffusion and the random permeable barrier model.Scientific reports · 2024Article
- Review of Reliable and Valid Noninvasive Tools for the Diagnosis of Chronic Exertional Compartment Syndrome.Orthopaedic journal of sports medicine · 2023Review
- Diffusion MRI fiber diameter for muscle denervation assessment.Quantitative imaging in medicine and surgery · 2022Article
- Update on sports imaging.Journal of clinical orthopaedics and trauma · 2021Article
- Differences between muscle from osteoporotic and osteoarthritic subjects: in vitro study by diffusion-tensor MRI and histological findings.Aging clinical and experimental research · 2020Article
- The Role of Magnetic Resonance in the Diagnosis of Chronic Exertional Compartment Syndrome.Revista brasileira de ortopedia · 2020Article
- Established paths and new avenues: a review of the main radiological techniques for investigating sarcopenia.Quantitative imaging in medicine and surgery · 2020Review
- Normal values and test-retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle.The British journal of radiology · 2019Article
- Diffusion tensor imaging and diffusion modeling: Application to monitoring changes in the medial gastrocnemius in disuse atrophy induced by unilateral limb suspension.Journal of magnetic resonance imaging : JMRI · 2019Article
- Spatially resolved kinetics of skeletal muscle exercise response and recovery with multiple echo diffusion tensor imaging (MEDITI): a feasibility study.Magma (New York, N.Y.) · 2018Article
- Normalized STEAM-based diffusion tensor imaging provides a robust assessment of muscle tears in football players: preliminary results of a new approach to evaluate muscle injuries.European radiology · 2018Article
- Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle.Magnetic resonance in medicine · 2018Article
- Advanced MRI Techniques for Muscle Imaging.Seminars in musculoskeletal radiology · 2017Review
- Validation of surface-to-volume ratio measurements derived from oscillating gradient spin echo on a clinical scanner using anisotropic fiber phantoms.NMR in biomedicine · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the performance of diffusion tensor imaging (DTI) in the evaluation of chronic exertional compartment syndrome (CECS) as compared to T2 -weighted (T2w) imaging. MATERIALS AND
methodsUsing an Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant protocol, spectral adiabatic inversion recovery (SPAIR) T2w imaging and stimulated echo DTI were applied to eight healthy volunteers and 14 suspected CECS patients before and after exertion. Longitudinal and transverse diffusion eigenvalues, mean diffusivity (MD), and fractional anisotropy (FA) were measured in seven calf muscle compartments, which in patients were classified by their response on T2w: normal (<20% change), and CECS (>20% change). Mixed model analysis of variance compared subject groups and compartments in terms of response factors (post/pre-exercise ratios) of DTI parameters.
resultsAll diffusivities significantly increased (P < 0.0001) and FA decreased (P = 0.0014) with exercise. Longitudinal diffusion responses were significantly smaller than transversal diffusion responses (P < 0.0001). Nineteen of 98 patient compartments were classified as CECS on T2w. MD increased by 3.8 ± 3.4% (volunteer), 7.4 ± 4.2% (normal), and 9.1 ± 7.0% (CECS) with exercise.
conclusionDTI shows promise as an ancillary imaging method in the diagnosis and understanding of the pathophysiology in CECS. Future studies may explore its utility in predicting response to treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.