ArticleCurrent anesthesiology reports2013
Sleep and Anesthesia Interactions: A Pharmacological Appraisal.
Article in Current anesthesiology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Esketamine during anesthesia induction improves early postoperative sleep quality in female patients undergoing laparoscopic surgery: A randomized trial.Pakistan journal of medical sciences · 2026Article
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Orexinergic projections to substantia innominata mediate arousal and analgesia.British journal of anaesthesia · 2025Article
- Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area.Frontiers in neuroscience · 2025Article
- Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Dopamine D1-receptor-expressing pathway from the nucleus accumbens to ventral pallidum-mediated sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2023Article
- Different Alterations of Hippocampal and Reticulo-Thalamic GABAergic Parvalbumin-Expressing Interneurons Underlie Different States of Unconsciousness.International journal of molecular sciences · 2023Article
- From molecule to oblivion: dedicated brain circuitry underlies anesthetic loss of consciousness permitting pain-free surgery.Frontiers in molecular neuroscience · 2023Review
- Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics.International journal of molecular sciences · 2022Review
- No cognitive processing in the unconscious, anesthetic-like, state of sleep.The Journal of comparative neurology · 2021Review
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep.Current opinion in neurobiology · 2017Review
- Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.The Journal of clinical investigation · 2017Article
- Effects of γ-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia.Anesthesiology · 2016Article
- The Role of Dopaminergic VTA Neurons in General Anesthesia.PloS one · 2015Article
- Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics.ACS chemical neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Anesthetics have been used in clinical practice for over a hundred years, yet their mechanisms of action remain poorly understood. One tempting hypothesis to explain their hypnotic properties posits that anesthetics exert a component of their effects by "hijacking" the endogenous arousal circuitry of the brain. Modulation of activity within sleep- and wake-related neuroanatomic systems could thus explain some of the varied effects produced by anesthetics. There has been a recent explosion of research into the neuroanatomic substrates affected by various anesthetics. In this review, we will highlight the relevant sleep architecture and systems and focus on studies over the past few years that implicate these sleep-related structures as targets of anesthetics. These studies highlight a promising area of investigation regarding the mechanisms of action of anesthetics and provide an important model for future study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.