Evidence map›Paper›PMID 23440616›Full record

ArticleClinical orthopaedics and related research2013

Success after treatment of periprosthetic joint infection: a Delphi-based international multidisciplinary consensus.

Claudio Diaz-Ledezma, Carlos A Higuera, Javad Parvizi

Registry-linked trialOpen access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Clinical orthopaedics and related research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02734134 (One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection), which is not on this map. Cited by 199 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02734134 nacompletednot on this mapstarted 2016, after this paper: background citation

One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection

TypeinterventionalSponsorOrthoCarolina Research Institute, Inc.Ran2016 to 2026Enrolled343ConditionsSurgical Site InfectionArmsOne-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 5 syntheses or guidelines pooled it, 401 citations in OpenAlex.

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  4. International journal of molecular sciences · 2023
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  17. The presence of a positive blood culture should be regarded a risk factor for DAIR failure in cases of haematogenous total knee arthroplasty infection.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026
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139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claudio Diaz-LedezmaThe Rothman Institute of Orthopaedics at Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Carlos A Higuera
Javad Parvizi
Rothman Institute · USThomas Jefferson University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe lack of agreement regarding what constitutes successful treatment for periprosthetic joint infections (PJI) makes it difficult to compare the different strategies of management that are used in clinical practice and in research studies. QUESTIONS/PURPOSES: The aims of this study were to create a consensus definition for success after PJI treatment, and to provide a universal, multidimensional framework for reporting of studies regarding PJI treatment.

methodsA two-round basic Delphi method was used to reach a consensus definition. We invited 159 international experts (orthopaedic surgeons, infectious disease specialists, and clinical researchers) from 17 countries to participate; 59 participated in the first round, and 42 participated in the second round. The final definition consisted of all statements that achieved strong agreement (80% or greater of participants considering a criterion relevant for defining success).

resultsThe consensus definition of a successfully treated PJI is: (1) infection eradication, characterized by a healed wound without fistula, drainage, or pain, and no infection recurrence caused by the same organism strain; (2) no subsequent surgical intervention for infection after reimplantation surgery; and (3) no occurrence of PJI-related mortality (by causes such as sepsis, necrotizing fasciitis). The Delphi panel agreed to defining midterm results as those reported 5 or more years after the definitive PJI surgery, and long-term results as those reported 10 or more years after surgery. Although no consensus was reached on the definition of short-term results, 71% of the participants agreed that 2 years after the definitive PJI surgery is acceptable to define it.

conclusionsThis multidimensional definition of success after PJI treatment may be used to report and compare results of treatment of this catastrophic complication. LEVEL OF EVIDENCE: Level V, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

Indexed as

Cooperative BehaviorDelphi TechniqueInterdisciplinary CommunicationArthroplasty, ReplacementHealth Care SurveysHumansJoint ProsthesisProsthesis-Related InfectionsRecurrenceReoperationSurveys and QuestionnairesTime FactorsTreatment OutcomeWound Healing

Identifiers

PMID23440616
PMCPMC3676607
OpenAlexW1981392377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.