Evidence map›Paper›PMID 23440612›Full record

ArticleCurrent topics in genetics2012

Regulatory genomics: Insights from the zebrafish.

Sumantra Chatterjee, Thomas Lufkin

Abstract read
In one paragraph

Article in Current topics in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sumantra ChatterjeeStem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, 138672, Singapore.
Thomas Lufkin
Agency for Science, Technology and Research · SGGenome Institute of Singapore · SG

Funding

DLX HOMEOBOX GENE CONTROL OF FETAL SKELETOGENESISR01DE013741 · NIDCR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI LUFKIN, THOMAS C · 2000 to 2004
$1.5M
NIDCR NIH HHS R01 DE013741
6 · The paper itself

Abstract

The sequencing of many vertebrate species over the last decade has opened up the possibility of using comparative genomics as a powerful tool to elucidate regulatory elements in the vertebrate genome. The zebrafish has played a pivotal role in this process. Its genome has been used in large-scale genome comparisons to locate vertebrate specific regulatory elements and also it has been an excellent model system to test out the predicted DNA sequences for their ability to drive reporter gene expression in vivo. In spite of all the successes there have still been some issues in using the zebrafish as a model system for these kinds of assays. This review will shed some light on the successes and failures of the zebrafish in pushing forward regulatory genomics.

Indexed as

bacterial artificial chromosomes (BACs)cis-regulatory elementshistone modificationszebrafish

Identifiers

PMID23440612
PMCPMC3577074
OpenAlexW1549042316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.