SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2013
A systematic review of comparative studies on bone graft alternatives for common spine fusion procedures.
Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03407560 (Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of platelet-rich plasma in posterior lumbar interbody fusion: systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Pooled it
- Platelet concentrates in spine fusion: meta-analysis of union rates and complications in controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Pooled it
- Clinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts versus synthetic or highly-processed xenogeneic bone grafts.BMC musculoskeletal disorders · 2016Trial
- Do Cellular Allografts Improve Spinal Fusion Enough to Justify Their Cost and Potential Risk? A Systematic Review of Efficacy, Safety, and Cost.Neurosurgery practice · 2026Review
- The impact of bone graft volume on risk of pseudarthrosis, screw loosening, and rod breakage in surgical correction of adult spinal deformity.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- What Graft Should Be Used in Pediatric Posterior Spinal Fusion? Current Trends and Perspective Among Experts.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- A critical review of the methodology of ovine lumbar interbody fusion studies and recommendations for future study design.Bone & joint research · 2026Article
- The Role of Crosslinked Collagen-Hydroxyapatite on the Properties of Tissue Graft Material.Acta medica Philippina · 2026Article
- Comparative Osteoinductive Potential of BMP-2, Bioactive Glass, and Demineralized Bone Matrix: An In Vitro Alkaline Phosphatase Assay Study.International journal of spine surgery · 2025Article
- Article
- The Evidence for the Use of Osteobiologics in Hybrid Constructs (Anterior Cervical Discectomy and Fusion and Total Disc Replacement) in Multilevel Cervical Degenerative Disc Disease: A Systematic Review.Global spine journal · 2024Article
- Comparative evaluation of multi-fold rib and structural iliac bone grafts in single-segment thoracic and thoracolumbar spinal tuberculosis: clinical and radiological outcomes.Journal of orthopaedic surgery and research · 2023Article
- Anterior Cervical Discectomy and Fusion Performed Using a CaO-SiOJournal of clinical medicine · 2023Article
- The benefit of antibiotic-combined Mg-hydroxyapatite bone graft substitute over autologous bone for surgical site infection prevention in posterolateral spinal fusion: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- Article
- Osteochondral allograft transplantation for complex distal humeral fractures assisted by 3D computer planning and printing technology: technical note.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022Article
- Hydroxyapatite Use in Spine Surgery-Molecular and Clinical Aspect.Materials (Basel, Switzerland) · 2022Review
- Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study.Frontiers in bioengineering and biotechnology · 2022Article
- Structural Allograft Versus PEEK Implants in Anterior Cervical Discectomy and Fusion: A Systematic Review.Global spine journal · 2020Article
- Clinical and radiographic evaluation of bioactive glass in posterior cervical and lumbar spinal fusion.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increased prevalence of spinal fusion surgery has created an industry focus on bone graft alternatives. While autologous bone graft remains the gold standard, the complications and morbidity from harvesting autologous bone drives the search for reliable and safe bone graft substitutes. With the recent information about the adverse events related to bone morhogenetic protein use, it is appropriate to review the literature about the numerous products that are not solely bone morphogenetic protein. PURPOSE: The purpose of this literature review is to determine the recommendations for use of non-bone morphogenetic protein bone graft alternatives in the most common spine procedures based on a quantifiable grading system. STUDY
designSystematic literature review.
methodsA literature search of MEDLINE (1946-2012), CINAHL (1937-2012), and the Cochrane Central Register of Controlled Trials (1940-April 2012) was performed, and this was supplemented by a hand search. The studies were then evaluated based on the Guyatt criteria for quality of the research to determine the strength of the recommendation.
resultsIn this review, more than one hundred various studies on the ability of bone graft substitutes to create solid fusions and good patient outcomes are detailed.
conclusionThe recommendations for use of bone graft substitutes and bone graft extenders are based on the strength of the studies and given a grade.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.