Evidence map›Paper›PMID 23440291›Full record

ArticleDer Pathologe2013

[Serrated polyps of the duodenum. Three cases with immunohistological and molecular pathological findings].

M Sarbia, S Jüttner, M Bettstetter, R Berndt

Abstract readEnglish Abstract
PubMed Publisher
In one paragraph

Article in Der Pathologe, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.International journal of molecular sciences · 2021
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M SarbiaPathologie München-Nord, Ernst-Platz-Strasse 2, Munich, Germany. sarbia@pathologie-muenchen.de
S Jüttner
M Bettstetter
R Berndt
Ansbach University of Applied Sciences · DEPathologie Hamburg-West · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report on three cases of serrated polyps of the duodenum which were incidental endoscopic findings in three male patients with a median age of 70 years (range 63-84 years). Architecturally the histological findings in cases 1 and 2 were similar to hyperplastic polyps of the colon. In case 3 there was a low grade intraepithelial neoplasia which covered the whole polyp. This polyp relapsed after 2 years with similar histological findings. Immunohistochemically an increased proliferative activity was found in case 3 as well as associated overexpression of p16 (INK4a) and p53. No abnormal expression of MLH1 and β-catenin was found in any of the polyps. Molecular pathological analysis showed a BRAF mutation (V600E) in case 3. A wild type sequence in the KRAS gene was found in all polyps. In conclusion, serrated polyps should be included in the diagnostic spectrum of benign duodenal polyps.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCarcinoma in SituCyclin-Dependent Kinase Inhibitor p16DNA Mutational AnalysisDuodenal NeoplasmsDuodenoscopyDuodenumGene ExpressionHumansIncidental FindingsIntestinal MucosaIntestinal PolypsMaleMiddle AgedBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16Tumor Suppressor Protein p53

Identifiers

PMID23440291
OpenAlexW140554096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.