ArticlePsychosomatic medicine2013
Examining the relationship between depression and asthma exacerbations in a prospective follow-up study.
Article in Psychosomatic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00459368 (Adherence Feedback for Improving Respiratory Medication Use), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adherence Feedback for Improving Respiratory Medication Use
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Safety outcomes of salbutamol: A systematic review and meta-analysis.The clinical respiratory journal · 2023Pooled it
- Effects of Comorbidities on Asthma Hospitalization and Mortality Rates: A Systematic Review.Canadian respiratory journal · 2018Pooled it
- A Randomized, Double-Blind, Placebo-Controlled Trial of Escitalopram in Patients with Asthma and Major Depressive Disorder.The journal of allergy and clinical immunology. In practiceTrial
- Prevalence of anxiety and depression among in-patient and out-patient asthmatic patients in Jordan: A cross-sectional study.Medicine · 2026Article
- Association between mental health disorders and asthma exacerbations in adults: a retrospective cohort study in UK primary care.BMJ open respiratory research · 2025Article
- Association between depression and asthma: insight from observational and genetic evidence.BMC psychiatry · 2025Observational
- Longitudinal Associations Between Depression and Religiosity/Spirituality Among Individuals with Asthma in the United States.Journal of religion and health · 2024Article
- Risk factors for asthma-related hospital and intensive care admissions in children, adolescents and adults: a cohort study using primary and secondary care data.BMJ open respiratory research · 2024Article
- Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Review
- Asthma medication adherence, control, and psychological symptoms: a cross-sectional study.BMC pulmonary medicine · 2024Article
- Heritability and genetic contribution analysis of structural-functional coupling in human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Psychological distress and symptom-related burnout in asthma during the COVID-19 pandemic.Journal of behavioral medicine · 2023Article
- Assessing the Efficacy and Safety of a Digital Therapeutic for Symptoms of Depression in Adolescents: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Anxiety, depression and global distress among African American young adults with uncontrolled asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Assessment of the Current Practice of Managing Depression in Patients with Asthma in Saudi Arabia: Physicians' Views.Journal of asthma and allergy · 2023Article
- Article
- Anxiety, depression, and asthma: New perspectives and approaches for psychoneuroimmunology research.Brain, behavior, & immunity - health · 2021Article
- Nonrespiratory Comorbidities in Asthma.The journal of allergy and clinical immunology. In practice · 2021Review
- Psycho-demographic profile in severe asthma and effect of emotional mood disorders and hyperventilation syndrome on quality of life.BMC psychology · 2021Article
- Genetic liability to major depression and risk of childhood asthma.Brain, behavior, and immunity · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundAlthough depression has been linked with asthma, its relationship with asthma exacerbations, including emergency department (ED) visits and oral steroid (OS) use, has not been well documented. The aim is to investigate whether depression increases exacerbations among patients with asthma.
methodThe study included 568 participants with asthma who were between 18 and 56 years old, were taking an inhaled corticosteroid, and participated in baseline and follow-up surveys. Surveys and medical records from a large, health system were collected as part of the Adherence Feedback for Improving Respiratory Medication Use trial. Number of ED visits and OS prescription fills for asthma were calculated for 12-month periods before and after the follow-up survey. Depression was measured using a standardized two-item instrument. Negative binomial regression and modified proportional hazards models were used.
resultsAmong patients with asthma, those who had depression (n = 187; 32.9%) were at increased risk for an asthma-related ED visit (adjusted relative risk = 1.96, 95% confidence interval [CI] = 1.02-3.75), but not an OS fill (adjusted relative risk = 0.98; 95% CI = 0.72-1.32). Participants with depression and asthma who received psychiatric treatment via antidepressant medication (n = 126; 22.2%) or psychotherapy (n = 39; 6.9%) were more likely to have an ED visit (medication hazard ratio = 2.09, 95% CI = 1.35-3.25; psychotherapy hazard ratio = 2.07, 95% CI = 1.38-3.22).
conclusionsThis study suggests a temporal relationship between depression and asthma-related ED visits. Research and practice must consider the importance of these comorbid conditions. Trial Registration ClinicalTrials.gov identifier: NCT00459368.
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Registered trials
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