Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Syllabic discrimination in premature human infants prior to complete formation of cortical layers.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
132 citing papers in PubMed, 2 syntheses or guidelines pooled it, 397 citations in OpenAlex.
- Functional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review.American journal of speech-language pathology · 2020Pooled it
- Functional Brain Connectivity of Language Functions in Children Revealed by EEG and MEG: A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- The increased inter-brain neural synchronization in prefrontal cortex between simulated patient and acupuncturist during acupuncture stimulation: Evidence from functional near-infrared spectroscopy hyperscanning.Human brain mapping · 2023Trial
- Trial
- Auditory stimuli mimicking ambient sounds drive temporal "delta-brushes" in premature infants.PloS one · 2013Trial
- Inter-brain coupling tracks emotional co-regulation.Cognitive, affective & behavioral neuroscience · 2026Article
- The impact of prenatal and postnatal acoustic experience to the discrimination of native versus non-native linguistic rules in the brain: insights from combined electrophysiological and vascular signals in 3-month-olds.Developmental cognitive neuroscience · 2026Article
- Brain-to-Brain Coupling Is Associated With the Benefits of Delayed Imitation in Skill Acquisition: An fNIRS Study.Brain and behavior · 2026Article
- Understanding variability in full-term newborns' fNIRS data: the impact of birth weight and gestational age on infants' speech perception abilities.Neurophotonics · 2026Article
- Verbal Episodic Processing in Newborns.eLife · 2026Article
- Prenatal Volume in the Bilateral Superior Temporal Gyrus Associates With Children's Expressive Vocabulary at 24-36 Months.Developmental science · 2026Article
- Enhanced word learning and neural synchrony during children's storytelling.NPJ science of learning · 2026Article
- Dynamics of the attentional blink in preverbal infants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Rhythm Processing Across Development: Origins, Links to Language Processing, and Perspectives for Intervention.Annals of the New York Academy of Sciences · 2026Review
- Reward-related language processing of maternal speech in infants at different likelihood of ASD.Social cognitive and affective neuroscience · 2026Article
- The auditory environment drives superior temporal sulcus depth in the neonatal period.Brain structure & function · 2025Article
- A computational model of radial scaffolds in the human fetal brain based on MRI.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Interpersonal neural synchronization underlies interactive concept learning in older adults.NPJ science of learning · 2025Article
- Assessment of resting state structural-functional relationships in perisylvian region during the early weeks after birth.Brain structure & function · 2025Article
- Neural encoding of auditory rhythm beyond cortical auditory areas before the age of term.iScience · 2025Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ontogeny of linguistic functions in the human brain remains elusive. Although some auditory capacities are described before term, whether and how such immature cortical circuits might process speech are unknown. Here we used functional optical imaging to evaluate the cerebral responses to syllables at the earliest age at which cortical responses to external stimuli can be recorded in humans (28- to 32-wk gestational age). At this age, the cortical organization in layers is not completed. Many neurons are still located in the subplate and in the process of migrating to their final location. Nevertheless, we observed several points of similarity with the adult linguistic network. First, whereas syllables elicited larger right than left responses, the posterior temporal region escaped this general pattern, showing faster and more sustained responses over the left than over the right hemisphere. Second, discrimination responses to a change of phoneme (ba vs. ga) and a change of human voice (male vs. female) were already present and involved inferior frontal areas, even in the youngest infants (29-wk gestational age). Third, whereas both types of changes elicited responses in the right frontal region, the left frontal region only reacted to a change of phoneme. These results demonstrate a sophisticated organization of perisylvian areas at the very onset of cortical circuitry, 3 mo before term. They emphasize the influence of innate factors on regions involved in linguistic processing and social communication in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.