ArticleJournal of experimental botany2013
The Arabidopsis CDK inhibitor ICK3/KRP5 is rate limiting for primary root growth and promotes growth through cell elongation and endoreduplication.
Article in Journal of experimental botany, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Stem cell regulators drive a G1 duration gradient during plant root development.Nature plants · 2025Article
- Developmental cues are encoded by the combinatorial phosphorylation of Arabidopsis RETINOBLASTOMA-RELATED protein RBR1.The EMBO journal · 2024Article
- AtHSPR functions in gibberellin-mediated primary root growth by interacting with KNAT5 and OFP1 in Arabidopsis.Plant cell reports · 2023Article
- Characterization of the soybean KRP gene family reveals a key role for GmKRP2a in root development.Frontiers in plant science · 2023Article
- Serine Hydroxymethyltransferase 1 Is Essential for Primary-Root Growth at Low-Sucrose Conditions.International journal of molecular sciences · 2022Article
- Potent inhibition of TCP transcription factors by miR319 ensures proper root growth in Arabidopsis.Plant molecular biology · 2022Article
- Connections between the Cell Cycle and the DNA Damage Response in Plants.International journal of molecular sciences · 2021Review
- Transcriptomic Analysis of Radish (Plants (Basel, Switzerland) · 2021Article
- Seeds and the Art of Genome Maintenance.Frontiers in plant science · 2019Review
- Identification of Loci and Candidate Genes Responsible for Fiber Length in Upland Cotton (Frontiers in plant science · 2019Article
- Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule.PLoS genetics · 2018Article
- Cell cycle arrest in plants: what distinguishes quiescence, dormancy and differentiated G1?Annals of botany · 2017Review
- Why do plants need so many cyclin-dependent kinase inhibitors?Plant signaling & behavior · 2017Article
- Plant Cyclin-Dependent Kinase Inhibitors of the KRP Family: Potent Inhibitors of Root-Knot Nematode Feeding Sites in Plant Roots.Frontiers in plant science · 2017Review
- Comparative Leaf and Root Transcriptomic Analysis of two Rice Japonica Cultivars Reveals Major Differences in the Root Early Response to Osmotic Stress.Rice (New York, N.Y.) · 2016Article
- The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots.The Plant cell · 2016Article
- Re-induction of the cell cycle in the Arabidopsis post-embryonic root meristem is ABA-insensitive, GA-dependent and repressed by KRP6.Scientific reports · 2016Article
- The RNA helicase, eIF4A-1, is required for ovule development and cell size homeostasis in Arabidopsis.The Plant journal : for cell and molecular biology · 2015Article
- Ethylene Inhibits Cell Proliferation of the Arabidopsis Root Meristem.Plant physiology · 2015Article
- Spatial Regulation of Root Growth: Placing the Plant TOR Pathway in a Developmental Perspective.International journal of molecular sciences · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The coordination of plant cell division and expansion controls plant morphogenesis, development, and growth. Cyclin-dependent kinases (CDKs) are not only key regulators of cell division but also play an important role in cell differentiation. In plants, CDK activity is modulated by the binding of INHIBITOR OF CDK/KIP-RELATED PROTEIN (ICK/KRP). Previously, ICK2/KRP2 has been shown to mediate auxin responses in lateral root initiation. Here are analysed the roles of all ICK/KRP genes in root growth. Analysis of ick/krp null-mutants revealed that only ick3/krp5 was affected in primary root growth. ICK3/KRP5 is strongly expressed in the root apical meristem (RAM), with lower expression in the expansion zone. ick3/krp5 roots grow more slowly than wildtype controls, and this results not from reduction of division in the proliferative region of the RAM but rather reduced expansion as cells exit the meristem. This leads to shorter final cell lengths in different tissues of the ick3/krp5 mutant root, particularly the epidermal non-hair cells, and this reduction in cell size correlates with reduced endoreduplication. Loss of ICK3/KRP5 also leads to delayed germination and in the mature embryo ICK3/KRP5 is specifically expressed in the transition zone between root and hypocotyl. Cells in the transition zone were smaller in the ick3/krp5 mutant, despite the absence of endoreduplication in the embryo suggesting a direct effect of ICK3/KRP5 on cell growth. It is concluded that ICK3/KRP5 is a positive regulator of both cell growth and endoreduplication.
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