ArticleLab on a chip2013
Measuring cell mechanics by optical alignment compression cytometry.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Straining Flow Effects on Sperm Flagellar Energetics in Microfluidic Cross-Slot Traps.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Microfluidic technologies for cell deformability cytometry.Smart medicine · 2022Review
- Tumbling and anomalous alignment of optically levitated anisotropic microparticles in chiral hollow-core photonic crystal fiber.Science advances · 2021Article
- Biomechanical Characterization at the Cell Scale: Present and Prospects.Frontiers in physiology · 2018Review
- Microfluidic techniques for high throughput single cell analysis.Current opinion in biotechnology · 2016Review
- An Automated High-throughput Array Microscope for Cancer Cell Mechanics.Scientific reports · 2016Article
- High-throughput linear optical stretcher for mechanical characterization of blood cells.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2016Article
- Mechanics of Biomimetic Liposomes Encapsulating an Actin Shell.Biophysical journal · 2015Article
- Effects of thermal noise on the transitional dynamics of an inextensible elastic filament in stagnation flow.Soft matter · 2015Article
- The Mechanobiology of Aging.Annual review of biomedical engineering · 2015Review
- Advances in high-throughput single-cell microtechnologies.Current opinion in biotechnology · 2014Review
- Viscoelasticity as a biomarker for high-throughput flow cytometry.Biophysical journal · 2013Article
- A Brief Review of the Biophysical Hallmarks of Metastatic Cancer Cells.Cancer hallmarks · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
To address the need for a high throughput, non-destructive technique for measuring individual cell mechanical properties, we have developed optical alignment compression (OAC) cytometry. OAC combines hydrodynamic drag in an extensional flow microfluidic device with optical forces created with an inexpensive diode laser to induce measurable deformations between compressed cells. In this, a low-intensity linear optical trap aligns incoming cells with the flow stagnation point allowing hydrodynamic drag to induce deformation during cell-cell interaction. With this novel approach, we measure cell mechanical properties with a throughput that improves significantly on current non-destructive individual cell testing methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.