ArticlePlant cell, tissue and organ culture2013
Cellular aggregation is a key parameter associated with long term variability in paclitaxel accumulation in Taxus suspension cultures.
Article in Plant cell, tissue and organ culture, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Changes in Cell Aggregation inPlants (Basel, Switzerland) · 2025Article
- The Occurrence, Uses, Biosynthetic Pathway, and Biotechnological Production of Plumbagin, a Potent Antitumor Naphthoquinone.Molecules (Basel, Switzerland) · 2025Review
- Taxane-Producing Fungi Isolated fromMicroorganisms · 2025Article
- The Interface amongst Conserved and Specialized Pathways in Non-Paclitaxel and Paclitaxel AccumulatingMetabolites · 2021Article
- Establishment of a Cell Suspension Culture ofPlants (Basel, Switzerland) · 2020Article
- Specialized Plant Metabolism Characteristics and Impact on Target Molecule Biotechnological Production.Molecular biotechnology · 2018Review
- Stable mitotic inheritance of rice minichromosomes in cell suspension cultures.Plant cell reports · 2015Article
- High-throughput sequencing reveals miRNA effects on the primary and secondary production properties in long-term subcultured Taxus cells.Frontiers in plant science · 2015Article
- Jasmonate-responsive expression of paclitaxel biosynthesis genes in Taxus cuspidata cultured cells is negatively regulated by the bHLH transcription factors TcJAMYC1, TcJAMYC2, and TcJAMYC4.Frontiers in plant science · 2015Article
- Methyl jasmonate represses growth and affects cell cycle progression in cultured Taxus cells.Plant cell reports · 2014Article
- Plant Cell Strain Improvement Through Engineering Biology for Industrial Plant Cell Culture.Engineering biologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Plant cell cultures provide a renewable source for synthesis and supply of commercially valuable plant-derived products, particularly for secondary metabolites. However, instability in product yields over multiple passages has hampered the efficient and sustainable use of this technology. Paclitaxel accumulation in Taxus cell suspension culture was quantified over multiple passages and correlated to mean aggregate size, extracellular sugar level, ploidy, and cell cycle distribution. Paclitaxel levels varied approximately 6.9-fold over the six-month timeframe investigated. Of all of the parameters examined, only mean aggregate size correlated with paclitaxel accumulation, where a significant negative correlation (r = - 0.75, p < 0.01) was observed. These results demonstrate the relevance of measuring, and potentially controlling, aggregate size during long term culture passages, particularly for plant suspensions where industrially relevant secondary metabolites are not pigmented to enable rapid culture selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.