ArticleVascular medicine (London, England)2013
Gender-related variation in the clinical presentation and outcomes of critical limb ischemia.
Article in Vascular medicine (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Results From the VISIBILITY Iliac Study: Primary and Cohort Outcomes at 9 Months.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2017Trial
- Sex Differences in Platelet Response to Common Antiplatelet Medications.Annals of vascular surgery · 2025Article
- Vascular Diseases in Women: Do Women Suffer from Them Differently?Journal of clinical medicine · 2024Review
- Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society.European heart journal · 2023Article
- A hidden problem: peripheral artery disease in women.European heart journal. Quality of care & clinical outcomes · 2023Review
- Focus on the Prevention of Acute Limb Ischemia: Centrality of the General Practitioner from the Point of View of the Internist.Journal of clinical medicine · 2023Review
- Predictors for the Development of Major Adverse Limb Events after Percutaneous Revascularization-Gender-Related Characteristics.Medicina (Kaunas, Lithuania) · 2023Article
- Increased long-term bleeding complications in females undergoing endovascular revascularization for peripheral arterial disease.Journal of vascular surgery · 2022Article
- Revascularization Techniques for Limb Salvage in Critical Limb Ischemia: A Single Institutional Study From Pakistan.Cureus · 2022Article
- Sex Differences in Myocardial and Vascular Aging.Circulation research · 2022Review
- Sex Differences in Peripheral Artery Disease.Circulation research · 2022Review
- Sex Differences in Trends and In-Hospital Outcomes Among Patients With Critical Limb Ischemia: A Nationwide Analysis.Journal of the American Heart Association · 2021Article
- Active smoking is associated with higher rates of incomplete wound healing after endovascular treatment of critical limb ischemia.Vascular medicine (London, England) · 2020Observational
- Sex-Related Differences in the Outcomes of Endovascular Interventions for Chronic Limb-Threatening Ischemia: Results from the LIBERTY 360 Study.Vascular health and risk management · 2020Observational
- Sex Differences in Outcomes Following Endovascular Treatment for Symptomatic Peripheral Artery Disease: An Analysis From the K- VIS ELLA Registry.Journal of the American Heart Association · 2019Observational
- Peripheral Arterial Disease in Women: an Overview of Risk Factor Profile, Clinical Features, and Outcomes.Current atherosclerosis reports · 2018Review
- Amputation trends for patients with lower extremity ulcers due to diabetes and peripheral artery disease using statewide data.Journal of vascular surgery · 2016Article
- Adherence to guideline-recommended therapies among patients with diverse manifestations of vascular disease.Vascular health and risk management · 2015Observational
- Endovascular therapy is effective treatment for focal stenoses in failing infrapopliteal vein grafts.Annals of vascular surgery · 2014Article
- Association of elevated fasting glucose with lower patency and increased major adverse limb events among patients with diabetes undergoing infrapopliteal balloon angioplasty.Vascular medicine (London, England) · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Critical limb ischemia (CLI) is a major cause of limb loss and mortality among patients with advanced peripheral artery disease. Our objective was to evaluate the gender-specific differences in patient characteristics and clinical outcomes among patients with CLI. We performed a retrospective analysis of 97 women and 122 men presenting with CLI who underwent angiography from 2006 to 2010. Baseline demographics, procedural details, and lesion characteristics were assessed for each patient. Kaplan-Meier analysis was used to assess long-term patient and lesion-level outcomes. Cox proportional hazard modeling was used to evaluate the relationship between gender and major adverse cardiovascular events (MACE). Compared to men, women were less likely to have a history of coronary artery disease (39% vs 54%, p = 0.02) or diabetes (57% vs 70%, p = 0.05) but had similar baseline medical therapy. At angiography, women were more likely to have significant femoropopliteal (77% vs 67%, p = 0.02) and multi-level infrainguinal disease (63% vs 51%, p = 0.02). Women were also more likely to undergo multi-vessel percutaneous intervention (69% vs 55%, p = 0.05), but had similar rates of limb salvage after percutaneous intervention or surgical bypass (HR 0.94 [95% CI 0.45-1.94], p = 0.9). During follow-up, women had higher rates of subsequent major adverse cardiovascular events (HR 1.63 [95% CI 1.01-2.63], p = 0.04). In conclusion, women with CLI are more likely to present with femoropopliteal and multi-level infrainguinal disease. Despite similar rates of limb salvage, women with CLI have an increased rate of subsequent major adverse cardiovascular events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.