ArticleHypertension (Dallas, Tex. : 1979)2013
Early interference with p44/42 mitogen-activated protein kinase signaling in hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension.
Article in Hypertension (Dallas, Tex. : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Mechanistic exploration of ubiquitination-mediated pathways in cerebral ischemic injury.Molecular biology reports · 2024Review
- IL (Interleukin)-17A Acts in the Brain to Drive Neuroinflammation, Sympathetic Activation, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Article
- PET-CT and RNA sequencing reveal novel targets for acupuncture-induced lowering of blood pressure in spontaneously hypertensive rats.Scientific reports · 2021Article
- An injectable microparticle formulation for the sustained release of the specific MEK inhibitor PD98059: in vitro evaluation and pharmacokinetics.Drug delivery and translational research · 2021Article
- Relationship Between Hematoma Expansion Induced by Hypertension and Hyperglycemia and Blood-brain Barrier Disruption in Mice and Its Possible Mechanism: Role of Aquaporin-4 and Connexin43.Neuroscience bulletin · 2020Article
- Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension.Frontiers in neuroscience · 2020Review
- (Pro)renin receptor knockdown in the paraventricular nucleus of the hypothalamus attenuates hypertension development and ATAmerican journal of physiology. Heart and circulatory physiology · 2019Article
- Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension.Neuroscience bulletin · 2019Review
- Central nervous system neuroplasticity and the sensitization of hypertension.Nature reviews. Nephrology · 2018Review
- Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats.Neuroscience · 2018Article
- Differential effects of long-term slow-pressor and subpressor angiotensin II on contractile and relaxant reactivity of resistance versus conductance arteries.Physiological reports · 2018Article
- TNF-α receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.American journal of physiology. Heart and circulatory physiology · 2017Article
- Renin-angiotensin system acting on reactive oxygen species in paraventricular nucleus induces sympathetic activation via AT1R/PKCγ/Rac1 pathway in salt-induced hypertension.Scientific reports · 2017Article
- Hypothalamic and inflammatory basis of hypertension.Clinical science (London, England : 1979) · 2017Review
- ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2016Article
- Central Renin-Angiotensin System Activation and Inflammation Induced by High-Fat Diet Sensitize Angiotensin II-Elicited Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Activation of central PPAR-γ attenuates angiotensin II-induced hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Hypothalamic signaling mechanisms in hypertension.Current hypertension reports · 2015Review
- Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Blood-borne angiotensin II (ANG II) can upregulate p44/42 mitogen-activated protein kinase (MAPK) signaling and ANG II type-1 receptors in the hypothalamic paraventricular nucleus (PVN), a critical cardiovascular and autonomic center. We tested the hypothesis that brain p44/42 MAPK signaling contributes to the development of ANG II-induced hypertension. The ANG II infusion (120 ng/kg per min, subcutaneously) induced increases in phosphorylated p44/42 MAPK and ANG II type-1 receptors in the PVN after 1 week, before the onset of hypertension, that were sustained as hypertension developed during a 2- or 3-week infusion protocol. Bilateral PVN microinjections of small interfering RNAs for p44/42 MAPK, at the onset of the ANG II infusion or 1 week later, prevented the early increase in p44/42 MAPK activity. The early treatment normalized ANG II type-1 receptor expression in the PVN and attenuated the hypertensive response to the 2-week infusion of ANG II. The later small interfering RNA microinjections had a transient effect on ANG II type-1 receptor expression in PVN and no effect on the hypertensive response to the 3-week infusion of ANG II. The early treatment also normalized the pressure response to ganglionic blockade. The ANG II infusion induced increases in mRNA for proinflammatory cytokines that were not affected by either small interfering RNA treatment. These results suggest that the full expression of ANG II-induced hypertension depends on p44/42 MAPK-mediated effects. A potential role for p44/42 MAPK in modulating the ANG II-induced central inflammatory response might also be considered. MAPK signaling in PVN may be a novel target for early intervention in the progression of ANG II-dependent hypertension.
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