ArticleThe American journal of pathology2013
Convergent replication of mouse synthetic prion strains.
Article in The American journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model.PLoS pathogens · 2024Article
- Eco-evolutionary trade-offs in the dynamics of prion strain competition.Proceedings. Biological sciences · 2023Article
- Prion strains: shining new light on old concepts.Cell and tissue research · 2023Review
- Structure of prion β-oligomers as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations.Proteomics · 2021Article
- Prion Strains and Transmission Barrier Phenomena.Pathogens (Basel, Switzerland) · 2018Review
- Evolutionary biology and the risk of scrapie disease in sheep.Open veterinary journal · 2018Review
- Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies.Pathogens (Basel, Switzerland) · 2017Review
- PrP P102L and Nearby Lysine Mutations Promote SpontaneousJournal of virology · 2017Article
- Biology and Genetics of PrP Prion Strains.Cold Spring Harbor perspectives in medicine · 2017Review
- Structural Biology of PrP Prions.Cold Spring Harbor perspectives in medicine · 2017Review
- Prion Strain Diversity.Cold Spring Harbor perspectives in medicine · 2016Review
- New Molecular Insight into Mechanism of Evolution of Mammalian Synthetic Prions.The American journal of pathology · 2016Article
- Two alternative pathways for generating transmissible prion disease de novo.Acta neuropathologica communications · 2015Article
- Generic amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prions.Scientific reports · 2015Article
- Article
- Truncated forms of the prion protein PrP demonstrate the need for complexity in prion structure.Prion · 2015Article
- Atypical and classical forms of the disease-associated state of the prion protein exhibit distinct neuronal tropism, deposition patterns, and lesion profiles.The American journal of pathology · 2013Article
- Drug resistance confounding prion therapeutics.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection.The Journal of biological chemistry · 2013Article
- Changes in prion replication environment cause prion strain mutation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Prion diseases are neurodegenerative disorders characterized by the aberrant folding of endogenous proteins into self-propagating pathogenic conformers. Prion disease can be initiated in animal models by inoculation with amyloid fibrils formed from bacterially derived recombinant prion protein. The synthetic prions that accumulated in infected organisms are structurally distinct from the amyloid preparations used to initiate their formation and change conformationally on repeated passage. To investigate the nature of synthetic prion transformation, we infected mice with a conformationally diverse set of amyloids and serially passaged the resulting prion strains. At each passage, we monitored changes in the biochemical and biological properties of the adapting strain. The physicochemical properties of each synthetic prion strain gradually changed on serial propagation until attaining a common adapted state with shared physicochemical characteristics. These results indicate that synthetic prions can assume multiple intermediate conformations before converging into one conformation optimized for in vivo propagation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.