ArticlePain medicine (Malden, Mass.)2013
Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats.
Article in Pain medicine (Malden, Mass.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Effect of Type and Dose of Exercise on Neuropathic Pain After Experimental Sciatic Nerve Injury: A Preclinical Systematic Review and Meta-Analysis.The journal of pain · 2023Pooled it
- Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis.Frontiers in immunology · 2023Pooled it
- Swimming Exercise Ameliorates Neuropathic Pain and Is Associated with Hippocampal H19, miR-22, and Wnt/β-Catenin Signaling.Neuromolecular medicine · 2026Article
- Swimming exercise alleviates peripheral neuropathic pain by downregulating FTO and promoting mThe journal of headache and pain · 2025Article
- Therapeutic synergy between swimming and photobiomodulation in a rat model of neuropathic pain.Lasers in medical science · 2025Article
- Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain.Scientific reports · 2025Article
- The role of walking exercise on axonal regrowth and neuropathic pain markers in dorsal root ganglion after sciatic nerve injury.Journal of exercise rehabilitation · 2023Article
- Effect of treadmill exercise on pain-related Wnt/β-catenin signaling pathway in dorsal root ganglion neurons at the early phase regeneration of the injured sciatic nerve.Journal of exercise rehabilitation · 2021Article
- Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research.Sports medicine - open · 2021Review
- Comparative Transcriptome Profiling Reveals Changes of microRNAs Response to Exercise in Rats with Neuropathic Pain.Neural plasticity · 2021Article
- [Effect of long-term resistance exercise on masseter muscle mechanical hyperalgesia in rats].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- Effects of voluntary exercise on antiretroviral therapy-induced neuropathic pain in mice.The journal of physiological sciences : JPS · 2018Article
- Swimming Training Reduces Neuroma Pain by Regulating Neurotrophins.Medicine and science in sports and exercise · 2018Article
- The Effects of Different Intensities of Exercise on Behavioral and Molecular Pain-Related Reactions in Rats: Implications for Medication Development.The Yale journal of biology and medicine · 2017Article
- Mesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia.Scientific reports · 2016Article
- Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats.Neurorehabilitation and neural repair · 2016Article
- Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain.Molecular pain · 2016Article
- Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain.Frontiers in neuroscience · 2016Review
- Review
- Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveNeuropathic pain is common and often difficult to treat because it generally does not respond well to the currently available pain medications or nerve blocks. Recent studies in both humans and animals have suggested that exercise may induce a transient analgesia and reduce acute pain in normal healthy individuals. We examined whether swim therapy could alleviate neuropathic pain in rats.
designRats were trained to swim over a 2-week period in warm water. After the rats were trained, neuropathic pain was induced by constricting the right sciatic nerve, and regular swimming was resumed. The sensitivity of each hind paw was monitored using the Hargreaves test and von Frey test to evaluate the withdrawal response thresholds to heat and touch.
resultsThe paw ipsilateral to the nerve ligation expressed pain-like behaviors including thermal hyperalgesia and mechanical allodynia. Regular swim therapy sessions significantly reduced the mechanical allodynia and thermal hyperalgesia. Swim therapy had little effect on the withdrawal thresholds for the contralateral paw. In addition, swim therapy alone did not alter the thermal or mechanical thresholds of normal rats.
conclusionsThe results suggest that regular exercise, including swim therapy, may be an effective treatment for neuropathic pain caused by nerve injuries. This study, showing that swim therapy reduces neuropathic pain behavior in rats, provides a scientific rationale for clinicians to test the efficacy of exercise in the management of neuropathic pain. It may prove to be a safe and cost-effective therapy in a variety of neuropathic pain states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.