ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2013
Is ignorance bliss? Depression, antidepressants, and the diagnosis of prediabetes and type 2 diabetes.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs.Diabetic medicine : a journal of the British Diabetic Association · 2021Pooled it
- Association of depression with pre-diabetes, undiagnosed diabetes, and previously diagnosed diabetes: a meta-analysis.Endocrine · 2016Pooled it
- Antidepressant medication as a risk factor for type 2 diabetes and impaired glucose regulation: systematic review.Diabetes care · 2013Pooled it
- ForgIng New paths in DIabetes PrevenTion (FINDIT): Study Protocol for a Randomized Controlled Trial.Trials · 2017Trial
- Omega-3 polyunsaturated fatty acids and mortality risk in depression: immune-inflammatory mediation in NHANES 1999-2018.Nutrition journal · 2025Article
- Diabetes beliefs, perceived risk and health behaviours: an embedded mixed-methods analysis from the Richmond Stress and Sugar Study.BMJ open · 2025Article
- Article
- Depressive Symptom Subgroups and Their Association with Prevalent and Incident Cardiovascular Risk Factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.International journal of behavioral medicine · 2023Article
- Sick and depressed? The causal impact of a diabetes diagnosis on depression.Health economics review · 2023Review
- Depressive symptoms mediate the relationship between diabetes and cognitive performance in a community-based sample of older adults.Journal of diabetes and its complications · 2022Article
- Investigating the association between diabetes and mental health: A train-and-test approach.Frontiers in psychiatry · 2022Article
- Is There Limited Utility for Lifestyle Recommendations for Diabetes Prevention Among Overweight or Obese Depressed Patients?Frontiers in medicine · 2021Article
- Association of Selective Serotonin Reuptake Inhibitors With the Risk of Type 2 Diabetes in Children and Adolescents.JAMA psychiatry · 2021Article
- Elevated depressive symptoms and risk of all-cause and cardiovascular mortality among adults with and without diabetes: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study.Journal of diabetes and its complications · 2020Article
- Subjective wellbeing as a determinant of glycated hemoglobin in older adults: longitudinal findings from the English Longitudinal Study of Ageing.Psychological medicine · 2020Article
- Glucose homeostasis in major depression and schizophrenia: a comparison among drug-naïve first-episode patients.European archives of psychiatry and clinical neuroscience · 2019Article
- Anaerobic muscle strengthening physical activity and depression severity among USA adults.Preventive medicine reports · 2018Article
- Discrimination and Depressive Symptoms Among African American Men Across the Adult Lifecourse.The journals of gerontology. Series B, Psychological sciences and social sciences · 2018Article
- The association of depression and diabetes across methods, measures, and study contexts.Clinical diabetes and endocrinology · 2018Article
- Fasting Glucose and the Risk of Depressive Symptoms: Instrumental-Variable Regression in the Cardiovascular Risk in Young Finns Study.International journal of behavioral medicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between clinically identified and undiagnosed prediabetes and Type 2 diabetes with depression and antidepressant medication use.
methodsData come from the National Health and Nutrition Examination Study (2005 and 2007), a population-based cross-sectional survey. Analysis is limited to adults aged 30 and older (n = 3,183, Mean age = 52.1 year). Depression syndrome was measured by the Patient Health Questionnaire-9. Participants were categorized using fasting glucose levels as normoglycemic (glucose <100 mg/dL), undiagnosed prediabetes (glucose 100-125.9), clinically identified prediabetes (glucose 100-125.9 plus clinician diagnosis), undiagnosed Type 2 diabetes (glucose >126), and clinically identified Type 2 diabetes (glucose >126 plus clinician diagnosis or use of antidiabetic medications). Health behaviors included smoking, poor diet, excessive alcohol use, and obesity. Health promotion behaviors included efforts to change diet, lose weight, and increase physical activity.
resultsClinically identified diabetes was associated with 4.3-fold greater odds of depression, but undiagnosed diabetes was not significantly associated with depression. This relationship was more pronounced for prediabetes. Clinically identified diabetes was associated with 1.8-fold greater odds of antidepressant use, but undiagnosed diabetes was not significantly associated with antidepressant use. Health behaviors were not consistently related to depression syndrome.
conclusionThe relationship between diabetes status and depression and antidepressant use depends on whether the diabetes has been clinically identified. Findings are consistent with the hypothesis that the relationship between diabetes and depression may be attributable to factors related to disease management. Previous reports linking antidepressants and diabetes may be attributable to clinical ascertainment bias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.