ArticlePloS one2013
Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing Hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed.
- Longitudinal genomic insights into resistance and virulence dynamics of Klebsiella pneumoniae clinical isolates from Pakistan.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Molecular Epidemiology of Carbapenem-ResistantInfection and drug resistance · 2026Article
- Emergence of ST11Microbiology spectrum · 2025Article
- Molecular characterization of antimicrobial resistance genes and plasmid profiles in enterobacterales isolated from urinary tract infections in rural outpatient women in Otavalo, Ecuador.BMC infectious diseases · 2025Article
- Resistance to aminoglycoside and quinolone drugs amongHeliyon · 2024Article
- Isolation and Identification of Multidrug-ResistantPathogens (Basel, Switzerland) · 2023Article
- Molecular typing methods & resistance mechanisms of MDRAIMS microbiology · 2023Review
- Characterization of Carbapenem-ResistantInfection and drug resistance · 2021Article
- Genotypic Characterization of ClinicalFrontiers in microbiology · 2021Article
- The genetic background of antibiotic resistance among clinical uropathogenic Escherichia coli strains.Molecular biology reports · 2018Article
- Prevalence ofAdvanced biomedical research · 2018Article
- Biofilm Formation inFrontiers in cellular and infection microbiology · 2018Article
- Failure of phylogeny inferred from multilocus sequence typing to represent bacterial phylogeny.Scientific reports · 2017Article
- Molecular Identification of Aminoglycoside-Modifying Enzymes and Plasmid-Mediated Quinolone Resistance Genes amongInternational journal of microbiology · 2017Article
- Genetic diversity of Klebsiella pneumoniae isolates during an outbreak in a non-human primate research colony.Journal of medical primatology · 2016Article
- Emergence of Klebsiella pneumoniae ST273 Carrying blaMicrobial drug resistance (Larchmont, N.Y.) · 2016Article
- High Prevalence of ESBL-ProducingFrontiers in microbiology · 2016Article
- Faecal carriage of carbapenemase-producing Gram-negative bacilli in hospital settings in southern France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.EMBO molecular medicine · 2015Article
- MLST-based inference of genetic diversity and population structure of clinical Klebsiella pneumoniae, China.Scientific reports · 2015Article
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6 authors.
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Abstract
backgroundThe genetic diversity and the clinical relevance of the drug-resistant Klebsiella pneumoniae isolates from hospital settings are largely unknown. We thus conducted this prospective study to analyze the molecular epidemiology of K. pneumoniae isolates from patients being treated in the 306 Hospital in Beijing, China for the period of November 1, 2010-October 31, 2011. METHODOLOGY/PRINCIPAL
findingsAntibiotic susceptibility testing, PCR amplification and sequencing of the drug resistance-associated genes, and multilocus sequence typing (MLST) were conducted. A total of 163 isolates were analyzed. The percentage of MDR, XDR and PDR isolates were 63.8% (104), 20.9 (34), and 1.8% (3), respectively. MLST results showed that 60 sequence types (STs) were identified, which were further separated by eBURST into 13 clonal complexes and 18 singletons. The most dominant ST was ST15 (10.4%). Seven new alleles and 24 new STs were first identified in this study. Multiple logistic regression analysis revealed that certain clinical characteristics were associated with those prevalent STs such as: from ICU, from medical ward, from community acquired infection, from patients without heart disease, from patients with treatment success, susceptible to extended spectrum cephalosporin, susceptible to cephamycins, susceptible to fluoroquinolones, and with MDR. CONCLUSIONS/SIGNIFICANCE: Our data indicate that certain drug-resistant K. pneumoniae clones are highly prevalent and are associated with certain clinical characteristics in hospital settings. Our study provides evidence demonstrating that intensive nosocomial infection control measures are urgently needed.
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