ArticlePloS one2013
Antioxidant effect of melatonin on the functional activity of colostral phagocytes in diabetic women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Melatonin and Lactation in Ruminants Dairy Animals: A Systematic Review and Meta-Analysis of Preclinical Studies.Health science reports · 2026Review
- Melatonin and Inflammatory Cytokines as Modulators of the Interaction Between Gestational Diabetes Mellitus and Pregnancy-Specific Urinary Incontinence.Metabolites · 2025Article
- The Role of Melatonin in the Inflammatory Process in Patients with Hyperglycemia and Leishmania Infection.Biomolecules · 2024Article
- Polarization of Melatonin-Modulated Colostrum Macrophages in the Presence of Breast Tumor Cell Lines.International journal of molecular sciences · 2023Article
- Leptin, Adiponectin, and Melatonin Modulate Colostrum Lymphocytes in Mothers with Obesity.International journal of molecular sciences · 2023Article
- Effects of Modified Melatonin Release on Human Colostrum Neutrophils to Induce Death in the MCF-7 Cell Line.International journal of cell biology · 2022Article
- Melatonin Hormone Acts on Cells of Maternal Blood and Placenta From Diabetic Mothers.Frontiers in physiology · 2021Article
- Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women.Medicina (Kaunas, Lithuania) · 2019Article
- Article
- Zika Virus Alters the Viscosity and Cytokines Profile in Human Colostrum.Journal of immunology research · 2019Article
- Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age.Parasitology research · 2018Article
- Intracellular calcium is a target of modulation of apoptosis in MCF-7 cells in the presence of IgA adsorbed to polyethylene glycol.OncoTargets and therapy · 2016Article
- Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers.Journal of immunology research · 2016Article
- Changes in the biochemical and immunological components of serum and colostrum of overweight and obese mothers.BMC pregnancy and childbirth · 2015Article
- The effect of IFN-γ and TGF-β in the functional activity of mononuclear cells in the presence of Entamoeba histolytica.Parasites & vectors · 2015Article
- Nanoparticles of barium induce apoptosis in human phagocytes.International journal of nanomedicine · 2015Article
- Microemulsion of babassu oil as a natural product to improve human immune system function.Drug design, development and therapy · 2015Article
- Effects of Momordica charantia L. on the blood rheological properties in diabetic patients.BioMed research international · 2014Article
- The role of cytokines in the functional activity of phagocytes in blood and colostrum of diabetic mothers.Clinical & developmental immunology · 2013Article
- Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts.Breast cancer research : BCR · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melatonin is involved in a number of physiological and oxidative processes, including functional regulation in human milk. The present study investigated the mechanisms of action of melatonin and its effects on the functional activity of colostral phagocytes in diabetic women. Colostrum samples were collected from normoglycemic (N = 38) and diabetic (N = 38) women. We determined melatonin concentration, superoxide release, bactericidal activity and intracellular Ca(2+) release by colostral phagocytes treated or not with 8-(Diethylamino) octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) and incubated with melatonin and its precursor (N-acetyl-serotonin-NAS), antagonist (luzindole) and agonist (chloromelatonin-CMLT). Melatonin concentration was higher in colostrum samples from hyperglycemic than normoglycemic mothers. Melatonin stimulated superoxide release by colostral phagocytes from normoglycemic but not hyperglycemic women. NAS increased superoxide, irrespective of glycemic status, whereas CMTL increased superoxide only in cells from the normoglycemic group. Phagocytic activity in colostrum increased significantly in the presence of melatonin, NAS and CMLT, irrespective of glycemic status. The bactericidal activity of colostral phagocytes against enterophatogenic Escherichia coli (EPEC) increased in the presence of melatonin or NAS in the normoglycemic group, but not in the hyperglycemic group. Luzindole blocked melatonin action on colostrum phagocytes. Phagocytes from the normoglycemic group treated with melatonin exhibited an increase in intracellular Ca(2+) release. Phagocytes treated with TMB-8 (intracellular Ca(2+) inhibitor) decreased superoxide, bactericidal activity and intracellular Ca(2+) release in both groups. The results obtained suggest an interactive effect of glucose metabolism and melatonin on colostral phagocytes. In colostral phagocytes from normoglycemic mothers, melatonin likely increases the ability of colostrum to protect against EPEC and other infections. In diabetic mothers, because maternal hyperglycemia modifies the functional activity of colostrum phagocytes, melatonin effects are likely limited to anti-inflammatory processes, with low superoxide release and bactericidal activity.
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