ArticlePloS one2013
Urinary phthalate metabolites are associated with body mass index and waist circumference in Chinese school children.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Association of exposure to phthalates with cardiometabolic risk factors in children and adolescents: a systematic review and meta-analysis.Environmental science and pollution research international · 2019Pooled it
- Hair-Based Biomonitoring of Phthalate Metabolites and Triclosan in Childhood: Links with Metabolic and Endocrine Disorders.Journal of xenobiotics · 2026Article
- Comprehensive analysis of human hepatotoxicity and mechanism of the plasticizer dimethyl phthalate.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- QuEChERS analytical approach for monitoring endocrine-disrupting chemicals in human urine.Analytical and bioanalytical chemistry · 2025Article
- Associations between environmental chemical mixtures and anthropometric measures in Korean girls: a cross-sectional study.European journal of pediatrics · 2025Article
- Hidden link between endocrine-disrupting chemicals and pediatric obesity.Clinical and experimental pediatrics · 2025Article
- Associations of Phthalate Exposure With Adiposity and Metabolic Syndrome in US Adolescents and Adults, NHANES 2013 to 2018.Journal of the Endocrine Society · 2024Article
- Time-trends in human urinary concentrations of phthalates and substitutes DEHT and DINCH in Asian and North American countries (2009-2019).Journal of exposure science & environmental epidemiology · 2023Article
- Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice.Environment international · 2023Article
- Phthalates in Glass Window Films of Chinese University Dormitories and Their Associations with Indoor Decorating Materials and Personal Care Products.International journal of environmental research and public health · 2022Article
- The p-Phthalates Terephthalic Acid and Dimethyl Terephthalate Used in the Manufacture of PET Induce In Vitro Adipocytes Dysfunction by Altering Adipogenesis and Thermogenesis Mechanisms.Molecules (Basel, Switzerland) · 2022Article
- Phthalate Metabolites in Urine of Chinese Children and Their Association with Asthma and Allergic Symptoms.International journal of environmental research and public health · 2022Article
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- Dietary intake and household exposures as predictors of urinary concentrations of high molecular weight phthalates and bisphenol A in a cohort of adolescents.Journal of exposure science & environmental epidemiology · 2022Article
- Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.Environmental health perspectives · 2021Article
- Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children of South Korea.Environmental science and pollution research international · 2021Article
- Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch School-Age Children.Obesity (Silver Spring, Md.) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLab studies have suggested that ubiquitous phthalate exposures are related to obesity, but relevant epidemiological studies are scarce, especially for children.
objectiveTo investigate the association of phthalate exposures with body mass index (BMI) and waist circumference (WC) in Chinese school children.
methodsA cross-sectional study was conducted in three primary and three middle schools randomly selected from Changning District of Shanghai City of China in 2011-2012. According to the physical examination data in October, 2011, 124 normal weight, 53 overweight, and 82 obese students 8-15 years of age were randomly chosen from these schools on the basis of BMI-based age- and sex-specific criterion. First morning urine was collected in January, 2012, and fourteen urine phthalate metabolites (free plus conjugated) were determined by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Multiple linear regression was used to explore the associations between naturally log-transformed urine phthalate metabolites and BMI or WC.
resultsThe urine specific gravity-corrected concentrations of nine urine phthalate metabolites and five molar sums were positively associated with BMI or WC in Chinese school children after adjustment for age and sex. However, when other urine phthalate metabolites were included in the models together with age and sex as covariables, most of these significant associations disappeared except for mono (2-ethylhexyl) phthalate (MEHP) and monoethyl phthalate (MEP). Additionally, some associations showed sex- or age-specific differences.
conclusionsSome phthalate exposures were associated with BMI or WC in Chinese school children. Given the cross-sectional nature of this study and lack of some important obesity-related covariables, further studies are needed to confirm the associations.
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