Evidence map›Paper›PMID 23437154›Full record

ArticlePloS one2013

Significant molecular and systemic adaptations after repeated sprint training in hypoxia.

Raphael Faiss, Bertrand Léger, Jean-Marc Vesin, Pierre-Etienne Fournier, Yan Eggel, Olivier Dériaz, Grégoire P Millet

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 140 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 11 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02241473 naunknown statusnot on this mapstarted 2014, after this paper: background citation

Changes in Body Composition, Metabolic and Mechanical Responses to Hypoxic Walking Training in Obese Patients

TypeinterventionalSponsorUniversity of LausanneRan2014 to 2015Enrolled30ConditionsObesityArmsTraining
NCT05439239 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Hypoxic Repeated Sprint Training on Performance in Normoxia in Male and Female Athletes Participating in Team/Racket Sports

TypeinterventionalSponsorUniversité Catholique de LouvainRan2022 to 2022Enrolled48ConditionsHypoxia, Repeated SprintsArmsRepeated sprint training
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 11 syntheses or guidelines pooled it, 280 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Muscle Oximetry in Sports Science: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2018
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Effects ofNutrients · 2026
    Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Raphael FaissISSUL-Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland. raphael.faiss@unil.ch
Bertrand Léger
Jean-Marc Vesin
Pierre-Etienne Fournier
Yan Eggel
Olivier Dériaz
Grégoire P Millet
Clinique Romande de Réadaptation · CHÉcole Polytechnique Fédérale de Lausanne · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While intermittent hypoxic training (IHT) has been reported to evoke cellular responses via hypoxia inducible factors (HIFs) but without substantial performance benefits in endurance athletes, we hypothesized that repeated sprint training in hypoxia could enhance repeated sprint ability (RSA) performed in normoxia via improved glycolysis and O(2) utilization. 40 trained subjects completed 8 cycling repeated sprint sessions in hypoxia (RSH, 3000 m) or normoxia (RSN, 485 m). Before (Pre-) and after (Post-) training, muscular levels of selected mRNAs were analyzed from resting muscle biopsies and RSA tested until exhaustion (10-s sprint, work-to-rest ratio 1:2) with muscle perfusion assessed by near-infrared spectroscopy. From Pre- to Post-, the average power output of all sprints in RSA was increased (p<0.01) to the same extent (6% vs 7%, NS) in RSH and in RSN but the number of sprints to exhaustion was increased in RSH (9.4±4.8 vs. 13.0±6.2 sprints, p<0.01) but not in RSN (9.3±4.2 vs. 8.9±3.5). mRNA concentrations of HIF-1α (+55%), carbonic anhydrase III (+35%) and monocarboxylate transporter-4 (+20%) were augmented (p<0.05) whereas mitochondrial transcription factor A (-40%), peroxisome proliferator-activated receptor gamma coactivator 1α (-23%) and monocarboxylate transporter-1 (-36%) were decreased (p<0.01) in RSH only. Besides, the changes in total hemoglobin variations (Δ[tHb]) during sprints throughout RSA test increased to a greater extent (p<0.01) in RSH. Our findings show larger improvement in repeated sprint performance in RSH than in RSN with significant molecular adaptations and larger blood perfusion variations in active muscles.

Indexed as

Adaptation, PhysiologicalHypoxiaAdultAthletesAthletic PerformanceGene ExpressionGlycolysisHemoglobinsHumansMaleMuscle, SkeletalOxygen ConsumptionPhysical EnduranceRNA, MessengerRunningSpectroscopy, Near-InfraredHemoglobinsRNA, Messenger

Identifiers

PMID23437154
PMCPMC3577885
OpenAlexW2078239955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.