SynthesisPloS one2013
Retention in care of HIV-infected children from HIV test to start of antiretroviral therapy: systematic review.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Attrition of HIV-positive children from HIV services in low and middle-income countries.AIDS (London, England) · 2019Pooled it
- Pooled it
- Implementation of antiretroviral therapy guidelines for under-five children in Tanzania: translating recommendations into practice.Journal of the International AIDS Society · 2015Guideline
- Interventions to improve or facilitate linkage to or retention in pre-ART (HIV) care and initiation of ART in low- and middle-income settings--a systematic review.Journal of the International AIDS Society · 2014Pooled it
- Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana.BMC public health · 2025Article
- Attrition and associated factors among children living with HIV at a tertiary hospital in Eritrea: a retrospective cohort analysis.BMJ paediatrics open · 2022Article
- Discordant retention of HIV-infected mothers and children: Evidence for a family-based approach from Southern Mozambique.Medicine · 2020Observational
- The future of a partially effective HIV vaccine: assessing limitations at the population level.International journal of public health · 2019Article
- Loss to follow-up among children in pre-ART care under the National AIDS Programme, Tamil Nadu, South India.Public health action · 2017Article
- Missed opportunities of inclusion in a cohort of HIV-infected children to initiate antiretroviral treatment before the age of two in West Africa, 2011 to 2013.Journal of the International AIDS Society · 2016Article
- The physical and psychological effects of HIV infection and its treatment on perinatally HIV-infected children.Journal of the International AIDS Society · 2015Article
- Immunodeficiency in children starting antiretroviral therapy in low-, middle-, and high-income countries.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Getting to 90-90-90 in paediatric HIV: What is needed?Journal of the International AIDS Society · 2015Article
- Research gaps in neonatal HIV-related care.Southern African journal of HIV medicine · 2015Article
- Mortality and Loss to Follow up Before Initiation of Antiretroviral Therapy Among HIV-Infected Children Eligible for HIV Treatment.Infectious disease reports · 2014Article
- Barriers to provider-initiated testing and counselling for children in a high HIV prevalence setting: a mixed methods study.PLoS medicine · 2014Article
- Provider-initiated HIV testing and counselling for children.PLoS medicine · 2014Article
- Article
- Article
- Immediate antiretroviral therapy in young HIV-infected children: benefits and risks.Current opinion in HIV and AIDS · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundIn adults it is well documented that there are substantial losses to the programme between HIV testing and start of antiretroviral therapy (ART). The magnitude and reasons for loss to follow-up and death between HIV diagnosis and start of ART in children are not well defined.
methodsWe searched the PubMed and EMBASE databases for studies on children followed between HIV diagnosis and start of ART in low-income settings. We examined the proportion of children with a CD4 cell count/percentage after after being diagnosed with HIV infection, the number of treatment-eligible children starting ART and predictors of loss to programme. Data were extracted in duplicate.
resultsEight studies from sub-Saharan Africa and two studies from Asia with a total of 10,741 children were included. Median age ranged from 2.2 to 6.5 years. Between 78.0 and 97.0% of HIV-infected children subsequently had a CD4 cell count/percentage measured, 63.2 to 90.7% of children with an eligibility assessment met the eligibility criteria for the particular setting and time and 39.5 to 99.4% of the eligible children started ART. Three studies reported an association between low CD4 count/percentage and ART initiation while no association was reported for gender. Only two studies reported on pre-ART mortality and found rates of 13 and 6 per 100 person-years.
conclusionMost children who presented for HIV care met eligibility criteria for ART. There is an urgent need for strategies to improve the access to and retention to care of HIV-infected children in resource-limited settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.