ArticlePloS one2013
Effects of polymorphisms -1112C/T and +2044A/G in interleukin-13 gene on asthma risk: a meta-analysis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis.BMC oral health · 2018Pooled it
- Interleukin-13 +2044 G/A and +1923C/T polymorphisms are associated with asthma susceptibility in Asians: A meta-analysis.Medicine · 2017Pooled it
- Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.PloS one · 2015Pooled it
- A meta-analysis of IL-13 polymorphisms and pediatric asthma risk.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Interleukin-6 -634C/G polymorphism is associated with lung cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between interleukin-4 receptor α chain (IL4RA) I50V and Q551R polymorphisms and asthma risk: an update meta-analysis.PloS one · 2013Pooled it
- IL5 rs2069812 and IL13 rs1800925 Genetic variants as key determinants of clinically relevant asthma phenotypes.PloS one · 2026Article
- Article
- Multiple sclerosis susceptibility may be associated with the coding rs20541 (R130Q) IL-13 gene polymorphism in the Polish population.Scientific reports · 2023Article
- Association of interleukin-13 gene single nucleotide polymorphism rs1800925 with allergic asthma in Asian population: A meta-analysis.Asia Pacific allergy · 2023Article
- Gene polymorphisms in asthma: a narrative review.Annals of translational medicine · 2022Review
- Relationship between interleukin-13 rs20541 single nucleotide polymorphisms and therapeutic efficacy in children with asthma.The Journal of international medical research · 2020Article
- Single Nucleotide and Copy-Number Variants in IL4 and IL13 Are Not Associated with Asthma Susceptibility or Inflammatory Markers: A Case-Control Study in a Mexican-Mestizo Population.Diagnostics (Basel, Switzerland) · 2020Article
- Association of IL-13 single nucleotide polymorphisms in Iranian patients to multiple sclerosis.American journal of clinical and experimental immunology · 2014Article
- Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity.Clinical epigenetics · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssociations between interleukin-13 (IL-13) polymorphisms and asthma risk remained controversial and ambiguous. Therefore, we performed a meta-analysis to assess the associations between IL-13 polymorphisms and asthma susceptibility.
methodsPubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model.
resultsThirty-four studies were included in this meta-analysis. The results indicated that IL13 -1112C/T polymorphism was significantly associated with asthma risk (OR=1.20, 95% CI 1.08-1.34, P=0.0009) in a dominant genetic model. When stratifying for race, IL13 -1112C/T polymorphism exhibited increased asthma risk in Caucasians (OR=1.30, 95% CI 1.09-1.55, P=0.003), while no significant association was found in Asians and African Americans. In the subgroup analysis based on atopic status, significant association was observed in atopic patients (OR=1.25, 95% CI 1.07-1.45, P=0.004) but not in the non-atopic patients. In addition, a significant association between IL13+2044A/G polymorphism and asthma risk was observed (OR=1.18, 95% CI 1.08-1.28, P=0.0002). In the subgroup analysis by ethnicity, there were significant associations between IL13+2044A/G polymorphism and asthma risk in Asians (OR=1.19, 95% CI 1.04-1.36, P=0.01) and Caucasians (OR=1.22, 95% CI 1.06-1.40, P=0.005) but not in African Americans. In the subgroup analysis stratified by atopic status, a marginal significant association was found in atopic patients (OR=1.12, 95% CI 1.00-1.26, P=0.05).
conclusionsThis meta-analysis suggested that the IL13 -1112C/T and +2044A/G polymorphisms were risk factors for asthma.
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