ArticlePloS one2013
Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Comparative effectiveness of H7N9 vaccines in healthy individuals.Human vaccines & immunotherapeutics · 2019Pooled it
- Divergent Avian Influenza H10 Viruses from Sympatric Waterbird Species in Italy: Zoonotic Potential Assessment by Molecular Markers.Microorganisms · 2025Article
- Cross-Species Transmission Risks of a Quail-Origin H7N9 Influenza Virus from China Between Avian and Mammalian Hosts.Viruses · 2025Article
- The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses.Cold Spring Harbor perspectives in medicine · 2021Review
- Inventory of molecular markers affecting biological characteristics of avian influenza A viruses.Virus genes · 2019Review
- A study of the relationship between human infection with avian influenza a (H5N6) and environmental avian influenza viruses in Fujian, China.BMC infectious diseases · 2019Article
- The re-emergence of highly pathogenic avian influenza H7N9 viruses in humans in mainland China, 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Detection of Low Pathogenicity Influenza A(H7N3) Virus during Duck Mortality Event, Cambodia, 2017.Emerging infectious diseases · 2018Article
- Avian influenza.EFSA journal. European Food Safety Authority · 2017Article
- First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site.Scientific reports · 2017Article
- A Novel A(H7N2) Influenza Virus Isolated from a Veterinarian Caring for Cats in a New York City Animal Shelter Causes Mild Disease and Transmits Poorly in the Ferret Model.Journal of virology · 2017Article
- New insights into influenza A specificity: an evolution of paradigms.Current opinion in structural biology · 2017Review
- Article
- Clinical, epidemiological and virological characteristics of the first detected human case of avian influenza A(H5N6) virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Transmission of influenza A viruses.Virology · 2015Review
- Epidemiological and viral genome characteristics of the first human H7N9 influenza infection in Guangdong Province, China.Journal of thoracic disease · 2014Article
- Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.Trends in microbiology · 2014Review
- Analysis of the full-length genome of a novel strain of the H7N9 avian influenza virus.Experimental and therapeutic medicine · 2014Article
- Role of receptor binding specificity in influenza A virus transmission and pathogenesis.The EMBO journal · 2014Review
- Influenza H7N9 and H9N2 viruses: coexistence in poultry linked to human H7N9 infection and genome characteristics.Journal of virology · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In the context of recently emerged novel influenza strains through reassortment, avian influenza subtypes such as H5N1, H7N7, H7N2, H7N3 and H9N2 pose a constant threat in terms of their adaptation to the human host. Among these subtypes, it was recently demonstrated that mutations in H5 and H9 hemagglutinin (HA) in the context of lab-generated reassorted viruses conferred aerosol transmissibility in ferrets (a property shared by human adapted viruses). We previously demonstrated that the quantitative binding affinity of HA to α2→6 sialylated glycans (human receptors) is one of the important factors governing human adaptation of HA. Although the H7 subtype has infected humans causing varied clinical outcomes from mild conjunctivitis to severe respiratory illnesses, it is not clear where the HA of these subtypes stand in regard to human adaptation since its binding affinity to glycan receptors has not yet been quantified. In this study, we have quantitatively characterized the glycan receptor-binding specificity of HAs from representative strains of Eurasian (H7N7) and North American (H7N2) lineages that have caused human infection. Furthermore, we have demonstrated for the first time that two specific mutations; Gln226→Leu and Gly228→Ser in glycan receptor-binding site of H7 HA substantially increase its binding affinity to human receptor. Our findings contribute to a framework for monitoring the evolution of H7 HA to be able to adapt to human host.
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