ArticlePLoS genetics2013
Ehd4 encodes a novel and Oryza-genus-specific regulator of photoperiodic flowering in rice.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed, 207 citations in OpenAlex.
- OsFTL1 integrates circadian and photoperiodic signals to optimize flowering time for ecological adaptation in rice.Plant communications · 2026Article
- An F-box protein OsFKF1 interacts with either OsGI or Hd1 and mediates the degradation of OsGI to control flowering time in rice.Science advances · 2026Article
- Unveiling stagnant flooding tolerance in lowland NERICAs: genomic insights and breeding prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
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- Rice Zinc-Finger Homeodomain 1 (OsZHD1) Finetunes Flowering Time by Modulating the Photoperiodic Response.Plant, cell & environment · 2025Article
- A combination of upstream alleles involved in rice heading hastens natural long-day responses.Genes & genomics · 2025Article
- A single-base deletion in exon 2 of Hd1 delineates monogenic recessive photoperiod insensitivity in aromatic Joha rice: a novel allele for seasonal adaptability.Biological research · 2024Article
- GmTRAB1, a Basic Leucine Zipper Transcription Factor, Positively Regulates Drought Tolerance in Soybean (Plants (Basel, Switzerland) · 2024Article
- Metabolomic and transcriptomic basis of photoperiodic response regulation in broomcorn millet (Panicum miliaceum L.).Scientific reports · 2024Article
- Research Progress on Photoperiod Gene Regulation of Heading Date in Rice.Current issues in molecular biology · 2024Review
- OsCOL5 suppresses heading through modulation of Ghd7 and Ehd2, enhancing rice yield.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Development of SNP genotyping assays for heading date in rice.Breeding science · 2024Article
- Article
- Unlocking allelic variation in circadian clock genes to develop environmentally robust and productive crops.Planta · 2024Review
- The WD40 domain-containing protein Ehd5 positively regulates flowering in rice (Oryza sativa).The Plant cell · 2023Article
- Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time.Plants (Basel, Switzerland) · 2023Review
- OsFTL12, a member of FT-like family, modulates the heading date and plant architecture by florigen repression complex in rice.Plant biotechnology journal · 2023Article
- Adaptation to high latitudes through a novel allele of Hd3a strongly promoting heading date in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- New Horizons in Plant Photoperiodism.Annual review of plant biology · 2023Review
47 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Land plants have evolved increasingly complex regulatory modes of their flowering time (or heading date in crops). Rice (Oryza sativa L.) is a short-day plant that flowers more rapidly in short-day but delays under long-day conditions. Previous studies have shown that the CO-FT module initially identified in long-day plants (Arabidopsis) is evolutionary conserved in short-day plants (Hd1-Hd3a in rice). However, in rice, there is a unique Ehd1-dependent flowering pathway that is Hd1-independent. Here, we report isolation and characterization of a positive regulator of Ehd1, Early heading date 4 (Ehd4). ehd4 mutants showed a never flowering phenotype under natural long-day conditions. Map-based cloning revealed that Ehd4 encodes a novel CCCH-type zinc finger protein, which is localized to the nucleus and is able to bind to nucleic acids in vitro and transactivate transcription in yeast, suggesting that it likely functions as a transcriptional regulator. Ehd4 expression is most active in young leaves with a diurnal expression pattern similar to that of Ehd1 under both short-day and long-day conditions. We show that Ehd4 up-regulates the expression of the "florigen" genes Hd3a and RFT1 through Ehd1, but it acts independently of other known Ehd1 regulators. Strikingly, Ehd4 is highly conserved in the Oryza genus including wild and cultivated rice, but has no homologs in other species, suggesting that Ehd4 is originated along with the diversification of the Oryza genus from the grass family during evolution. We conclude that Ehd4 is a novel Oryza-genus-specific regulator of Ehd1, and it plays an essential role in photoperiodic control of flowering time in rice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.