ArticlePLoS genetics2013
Lessons from Dwarf8 on the strengths and weaknesses of structured association mapping.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- A multi-omics approach to maize (Zea mays) tassel development.BMC plant biology · 2026Article
- Genetic control of wheat flour end-use quality and rheology by genome-wide association studies.The plant genome · 2026Article
- Genetic and phenotypic associations between peduncle characteristics and spike productivity in wheat under drought and normal conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Mapping novel yellow and leaf rust loci and predicting resistance in cross derived Canadian durum wheat.The plant genome · 2025Article
- Individual plant genetics reveal the control of local adaptation in European maize landraces.BMC biology · 2025Article
- Beyond the Standard GWAS-A Guide for Plant Biologists.Plant & cell physiology · 2025Review
- Gibberellins: extending the Green Revolution.Journal of experimental botany · 2025Review
- Genome-Wide Association Analyses Identify Hydrogen Peroxide-Responsive Loci in Wheat Diversity.Plant direct · 2025Article
- Identification of Elite Alleles and Candidate Genes for the Cotton Boll Opening Rate via a Genome-Wide Association Study.International journal of molecular sciences · 2025Article
- Hormonal influence on maize inflorescence development and reproduction.Plant reproduction · 2024Review
- Genome-wide scanning to identify and validate single nucleotide polymorphism markers associated with drought tolerance in spring wheat seedlings.The plant genome · 2024Article
- Dissecting the complex genetic basis of pre- and post-harvest traits inHorticulture research · 2024Article
- Genetic dissection of resistance to gray leaf spot by genome-wide association study in a multi-parent maize population.BMC plant biology · 2024Article
- Integrating Association Mapping, Linkage Mapping, Fine Mapping with RNA Seq Conferring Seedling Vigor Improvement for Successful Crop Establishment in Deep Sown Direct-Seeded Rice.Rice (New York, N.Y.) · 2023Article
- E-GWAS: an ensemble-like GWAS strategy that provides effective control over false positive rates without decreasing true positives.Genetics, selection, evolution : GSE · 2023Article
- Genome-Wide Association Study Identified Candidate Genes for Alkalinity Tolerance in Rice.Plants (Basel, Switzerland) · 2023Article
- Genetics of a diverse soft winter wheat population for pre-harvest sprouting, agronomic, and flour quality traits.Frontiers in plant science · 2023Article
- Genome-Wide Association Study Revealed SNP Alleles Associated with Seed Size Traits in African Yam Bean (Genes · 2022Article
- Transcriptional responses to gibberellin in the maize tassel and control by DELLA domain proteins.The Plant journal : for cell and molecular biology · 2022Article
- Genome-wide association studies of yield-related traits in high-latitude japonica rice.BMC genomic data · 2021Article
5 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
The strengths of association mapping lie in its resolution and allelic richness, but spurious associations arising from historical relationships and selection patterns need to be accounted for in statistical analyses. Here we reanalyze one of the first generation structured association mapping studies of the Dwarf8 (d8) locus with flowering time in maize using the full range of new mapping populations, statistical approaches, and haplotype maps. Because this trait was highly correlated with population structure, we found that basic structured association methods overestimate phenotypic effects in the region, while mixed model approaches perform substantially better. Combined with analysis of the maize nested association mapping population (a multi-family crossing design), it is concluded that most, if not all, of the QTL effects at the general location of the d8 locus are from rare extended haplotypes that include other linked QTLs and that d8 is unlikely to be involved in controlling flowering time in maize. Previous independent studies have shown evidence for selection at the d8 locus. Based on the evidence of population bottleneck, selection patterns, and haplotype structure observed in the region, we suggest that multiple traits may be strongly correlated with population structure and that selection on these traits has influenced segregation patterns in the region. Overall, this study provides insight into how modern association and linkage mapping, combined with haplotype analysis, can produce results that are more robust.
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