ArticleChembiochem : a European journal of chemical biology2013
Readily accessible fluorescent probes for sensitive biological imaging of hydrogen peroxide.
Article in Chembiochem : a European journal of chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hydrogen peroxide responsive theranostics for cancer-selective activation of DNA alkylators and real-time fluorescence monitoring in living cells.European journal of medicinal chemistry · 2024Article
- Boronates as hydrogen peroxide-reactive warheads in the design of detection probes, prodrugs, and nanomedicines used in tumors and other diseases.Drug delivery and translational research · 2023Review
- Protein transfection via spherical nucleic acids.Nature protocols · 2022Review
- Protein Spherical Nucleic Acids for Live-Cell Chemical Analysis.Journal of the American Chemical Society · 2020Article
- Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology.Frontiers in chemistry · 2020Review
- Microfabricated needle for hydrogen peroxide detection.RSC advances · 2019Article
- Factors Associated with Nitric Oxide-mediated β2 Integrin Inhibition of Neutrophils.The Journal of biological chemistry · 2015Article
- Exploiting oxidative microenvironments in the body as triggers for drug delivery systems.Antioxidants & redox signaling · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Hydrogen peroxide is a major component of oxygen metabolism in biological systems that, when present in high concentrations, can lead to oxidative stress in cells. Noninvasive molecular imaging of H(2)O(2) using fluorogenic systems represents an effective way to detect and measure the accumulation of this metabolite. Herein, we detail the development of robust H(2)O(2)-sensitive fluorescent probes using a boronic ester trigger appended to the fluorophore through a benzyl ether linkage. A major advantage of the probes presented here is their synthetic accessibility, with only one step needed to generate the probes on the gram scale. The sensitivity of the probes was evaluated in simulated physiological conditions, showing micromolar sensitivity to H(2)O(2). The probes were tested in biological model systems, demonstrating effective imaging of unstimulated, endogenous H(2)O(2) levels in RAW 264.7 cells and murine brain tissue.
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Registered trials
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