ArticleMethods in molecular biology (Clifton, N.J.)2013
DNase I digestion of isolated nulcei for genome-wide mapping of DNase hypersensitivity sites in chromatin.
Article in Methods in molecular biology (Clifton, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers.Development (Cambridge, England) · 2026Article
- XL-DNase-Seq: Footprinting Analysis of Dynamic Transcription Factors.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor.Genome biology · 2021Article
- DNA methylation variations in familial female and male breast cancer.Oncology letters · 2021Article
- Article
- Expression levels of circulatory mir-185-5p, vascular endothelial growth factor, and platelet-derived growth factor target genes in endometriosis.International journal of reproductive biomedicine · 2020Article
- Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion.Life science alliance · 2019Article
- Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer.BMC genomics · 2017Article
- Transcriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis.PloS one · 2017Article
- Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells.Genome research · 2016Article
- Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells.Scientific reports · 2016Article
- Effect of in ovo folic acid injection on hepatic IGF2 expression and embryo growth of broilers.Journal of animal science and biotechnology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
DNase I hypersensitivity (DHS) analysis is a powerful method to analyze chromatin structure and identify genomic regulatory elements. Integration of a high-throughput detection method into DHS analysis makes genome-wide mapping of DHS sites possible at a reasonable cost. Here we describe methods for DHS analysis carried out with mouse liver nuclei, involving DNase I digestion followed by isolation of DNase I-released DNA fragments suitable for high-throughput, next generation DNA sequencing (DNase-seq). A real-time PCR-based assay used to optimize DNase I digestion conditions is also described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.