ArticleGlycobiology2013
Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures.
Article in Glycobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01814540 (Pilot Study), which is not on this map. Cited by 94 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study: Tolerability of Feeding Different Doses of Bovine Milk Oligosaccharides for Modifying Gastrointestinal Function in Healthy Individuals
Who cites it
94 citing papers in PubMed.
- Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System-Related Oligosaccharides.The Journal of nutrition · 2020Trial
- Fecal metatranscriptomics and glycomics suggest that bovine milk oligosaccharides are fully utilized by healthy adults.The Journal of nutritional biochemistry · 2020Trial
- Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms.PloS one · 2019Trial
- Effects of Compound Milk Oligosaccharides on Growth Performance, Immune Function, and Intestinal Health of Neonatal Suckling Piglets with Different Birth Weights.Animals : an open access journal from MDPI · 2026Article
- Unraveling Cross-Ring Dissociation Mechanisms of Hexoses in Collision-Induced Dissociation.The journal of physical chemistry. A · 2026Article
- Review
- The Role of Dairy in Human Nutrition: Myths and Realities.Nutrients · 2025Review
- Unusual free trisaccharides in caprine colostrum discovered by logically derived sequence tandem mass spectrometry.Scientific reports · 2025Article
- Review
- Comparative Analysis of Angora Rabbit Colostrum and Mature Milk Using Quantitative Proteomics.Biology · 2024Article
- Synthesis of fucosyllactose using α-L-fucosidases GH29 from infant gut microbial metagenome.Applied microbiology and biotechnology · 2024Article
- Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review.World journal of clinical pediatrics · 2024Article
- Safety of lacto-N-fucopentaose I/2'-fucosyllactose (LNFP-I/2'-FL) mixture as a novel food pursuant to Regulation (EU) 2015/2283.EFSA journal. European Food Safety Authority · 2023Article
- Safety of 2'-fucosyllactose (2'-FL) produced by a derivative strain (EFSA journal. European Food Safety Authority · 2023Article
- Safety of 3'-sialyllactose (3'-SL) sodium salt produced by a derivative strain (EFSA journal. European Food Safety Authority · 2023Article
- Comparative analysis of oligosaccharides in the milk of human and animals by using LC-QE-HF-MS.Food chemistry: X · 2023Article
- Creation of a milk oligosaccharide database, MilkOligoDB, reveals common structural motifs and extensive diversity across mammals.Scientific reports · 2023Article
- Safety of 3-fucosyllactose (3-FL) produced by a derivative strain ofEFSA journal. European Food Safety Authority · 2023Article
- Safety of 6'-sialyllactose (6'-SL) sodium salt produced by a derivative strain (EFSA journal. European Food Safety Authority · 2023Article
- Safety of 6'-sialyllactose (6'-SL) sodium salt produced by derivative strains ofEFSA journal. European Food Safety Authority · 2022Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients. Recent studies revealed that bovine milk contains complex oligosaccharides structurally related to those previously thought to be present in only human milk. These BMOs are microbiotic modulators involved in important biological activities, including preventing pathogen binding to the intestinal epithelium and serving as nutrients for a selected class of beneficial bacteria. Only a small number of BMO structures are fully elucidated. To better understand the potential of BMOs as a class of biotherapeutics, their detailed structure analysis is needed. This study initiated the development of a structure library of BMOs and a comprehensive evaluation of structure-related specificity. The bovine milk glycome was profiled by high-performance mass spectrometry and advanced separation techniques to obtain a comprehensive catalog of BMOs, including several novel, lower abundant neutral and fucosylated oligosaccharides that are often overlooked during analysis. Structures were identified using isomer-specific tandem mass spectroscopy and targeted exoglycosidase digestions to produce a BMO library detailing retention time, accurate mass and structure to allow their rapid identification in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.