Evidence map›Paper›PMID 23436269›Full record

Trial reportJournal of clinical pharmacology2013

Population pharmacokinetic modeling of sertraline treatment in patients with Alzheimer disease: the DIADS-2 study.

Claire H Li, Bruce G Pollock, Constantine G Lyketsos, Vijay Vaidya, Lea T Drye, Margaret Kirshner, Denise Sorisio, Robert R Bies, DIADS-2 Research Group

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claire H LiDivision of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. clali@iupui.edu
Bruce G Pollock
Constantine G Lyketsos
Vijay Vaidya
Lea T Drye
Margaret Kirshner
Denise Sorisio
Robert R Bies
DIADS-2 Research Group

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Depression in Alzheimer's Disease Study 2 (DIADS-2)U01MH066136 · NIMH · JOHNS HOPKINS UNIVERSITY · PI LYKETSOS, CONSTANTINE G · 2003 to 2007
$2.2M
Depression in Alzheimer's Disease-IIU01MH068014 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MEINERT, CURTIS L · 2003 to 2007
$1.6M
Depression in Alzheimer's Disease Study 2 (DIADS-2)U01MH066175 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHNEIDER, LON S · 2003 to 2007
$600k
Depression in Alzheimer's Disease Study-2(DIADS-2)U01MH066174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WEINTRAUB, DANIEL · 2003 to 2007
$384k
Depressoin in Alzheimer's Disease Study-2 (DIADS-2)U01MH066176 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MINTZER, JACOBO E. · 2003 to 2007
$359k
Depression in Alzheimer's Disease Study 2 (DIADS-2)U01MH066177 · NIMH · UNIVERSITY OF ROCHESTER · PI PORSTEINSSON, ANTON P · 2003 to 2007
$317k
NIA NIH HHS P50 AG005146NIMH NIH HHS 1U01MH066136NIMH NIH HHS 1U01MH066174NIMH NIH HHS 1U01MH066175NIMH NIH HHS 1U01MH066176NIMH NIH HHS 1U01MH066177NIMH NIH HHS 1U01MH068014NIMH NIH HHS U01 MH066136NIMH NIH HHS U01 MH066174NIMH NIH HHS U01 MH066175NIMH NIH HHS U01 MH066176NIMH NIH HHS U01 MH066177NIMH NIH HHS U01 MH068014
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Models, BiologicalAgedAged, 80 and overAlzheimer DiseaseAntidepressive AgentsDepressionDouble-Blind MethodFemaleHumansMaleMiddle AgedSelective Serotonin Reuptake InhibitorsSertralineAntidepressive AgentsSelective Serotonin Reuptake InhibitorsSertraline

Identifiers

PMID23436269
PMCPMC3604147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.