ArticleHeart and vessels2014
Progressive aortic dilation and aortic stiffness in children with repaired tetralogy of Fallot.
Article in Heart and vessels, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Progression of Aortic Dilation in Patients with Tetralogy of Fallot with Pulmonary Atresia and Major Aortopulmonary Collateral Arteries.Pediatric cardiology · 2026Article
- Myocardial, Valvular and Vascular Abnormalities in Repaired Tetralogy of Fallot.Life (Basel, Switzerland) · 2024Review
- Serial Magnetic Resonance Imaging for Aortic Dilation in Tetralogy of Fallot With Pulmonary Stenosis.The American journal of cardiology · 2023Article
- Cord blood cardiovascular biomarkers in tetralogy of fallot and D-transposition of great arteries.Frontiers in pediatrics · 2023Article
- Mechanical and Structural Adaptation of the Pulmonary Root after Ross Operation in a Murine Model.Journal of clinical medicine · 2022Article
- The Surgical Strategy for Progressive Dilatation of Aortic Root and Aortic Regurgitation After Repaired Tetralogy of Fallot: A Case Report.Frontiers in cardiovascular medicine · 2022Article
- Follow-up aortic dilatation in patients with repaired tetralogy of Fallot using cardiovascular magnetic resonance.European journal of radiology open · 2021Article
- Aortic Vorticity, Helicity, and Aortopathy in Adult Patients with Tetralogy of Fallot: Pilot Study Using Four-Dimensional Flow Magnetic Resonance Images.Pediatric cardiology · 2021Article
- Increased systolic vorticity in the left ventricular outflow tract is associated with abnormal aortic flow formations in Tetralogy of Fallot.The international journal of cardiovascular imaging · 2020Article
- Aortopathy in tetralogy of Fallot-a collective review.Indian journal of thoracic and cardiovascular surgery · 2019Review
- Size and Stiffness of the Pulmonary Autograft after the Ross Procedure in Children.Pediatric cardiology · 2019Article
- Assessing utility of exercise test in determining exercise prescription in adolescent and adult patients with repaired tetralogy of fallot.Heart and vessels · 2017Article
- Holodiastolic Flow Reversal at the Descending Aorta on Cardiac Magnetic Resonance is Neither Sensitive Nor Specific for Significant Aortic Regurgitation in Patients with Congenital Heart Disease.Pediatric cardiology · 2016Article
- Comparison of pulse wave velocity assessed by three different techniques: Arteriograph, Complior, and Echo-tracking.Heart and vessels · 2016Article
- Higher oily fish consumption in late pregnancy is associated with reduced aortic stiffness in the child at age 9 years.Circulation research · 2015Article
- Realignment of the ventricular septum in tetralogy of Fallot using (partial) direct closure of the ventricular septal defect: Long-term follow-up and comparison to conventional patch repair.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progressive aortic dilation occurs in patients with tetralogy of Fallot (TOF), possibly due to abnormal histopathology of the aortic media that weakens the aortic wall. This medial histopathology may be reflected as aortic stiffness, which in turn may predict progressive aortic dilation. To test this theory, we studied the relationship between aortic wall stiffness, measured by pulse wave velocity (PWV), and subsequent aortic dilation in 32 consecutive patients with repaired TOF. The ascending aortic diameter (AOD) was obtained by two-dimensional transthoracic echocardiography performed at baseline and at the follow-up examination, 7.6 ± 2.0 years after baseline. TOF patients exhibited significantly greater AODs than normal reference values, at baseline (19.8 ± 5.0 vs 14.3 ± 3.1 mm; P = 0.0001) and at the follow-up examination (25.9 ± 3.8 vs 18.1 ± 2.4 mm; P = 0.0001). The observed change in AOD during the follow-up period (0.83 ± 0.43 mm/year) was significantly larger than the change that would be expected by the patient's growth (0.50 ± 0.25 mm/year; P = 0.0001). The PWV at baseline correlated positively with both AOD at follow-up (P = 0.0018) and the annual rate of aortic dilation (P = 0.0007). On multivariate regression analysis, PWV remained a significant and independent predictor of subsequent aortic dilation. These results suggest a causative role for aortic stiffening in the progressive aortic dilation noted in TOF, indicating that incorporating aortic stiffness as well as aortic diameter in the assessment of TOF aortopathy may help better define the need for, and the timing of, medical intervention.
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