ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Trajectories of femoral neck strength in relation to the final menstrual period in a multi-ethnic cohort.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Trajectories of areal bone mineral density significantly differ by patterning of femoral neck area and bone mineral content across the menopausal transition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- The association between age at menopause and bone health in Southwest China women: mediation effect of body mass index.BMC public health · 2024Article
- Changes in Collagen Type I C-Telopeptide and Procollagen Type I N-Terminal Propeptide During the Menopause Transition.The Journal of clinical endocrinology and metabolism · 2024Article
- Associations of Age at Menopause With Postmenopausal Bone Mineral Density and Fracture Risk in Women.The Journal of clinical endocrinology and metabolism · 2022Article
- The combined effects of age and HIV on the anatomic distribution of cortical and cancellous bone in the femoral neck among men and women.AIDS (London, England) · 2021Article
- Faster Lumbar Spine Bone Loss in Midlife Predicts Subsequent Fracture Independent of Starting Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2021Article
- Trabecular Bone Score Declines During the Menopause Transition: The Study of Women's Health Across the Nation (SWAN).The Journal of clinical endocrinology and metabolism · 2020Article
- The menopause transition and women's health at midlife: a progress report from the Study of Women's Health Across the Nation (SWAN).Menopause (New York, N.Y.) · 2019 · on this mapReview
- Article
- External Bone Size Is a Key Determinant of Strength-Decline Trajectories of Aging Male Radii.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Bone Health During the Menopause Transition and Beyond.Obstetrics and gynecology clinics of North America · 2018Review
- Femoral Neck External Size but not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Change in sexual functioning over the menopausal transition: results from the Study of Women's Health Across the Nation.Menopause (New York, N.Y.) · 2017Observational
- Socioeconomic status in relation to incident fracture risk in the Study of Women's Health Across the Nation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Physical activity as determinant of femoral neck strength relative to load in adult women: findings from the hip strength across the menopause transition study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Moving toward a prevention strategy for osteoporosis by giving a voice to a silent disease.Women's midlife healthArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
unlabelledThe purpose of this study was to describe the evolution of femoral neck strength relative to load across the menopause transition. It declined significantly over the 10 years bracketing the final menstrual period, and the rate of decline was modified by body mass index, race/ethnicity, and smoking status.
introductionComposite indices of femoral neck strength, which integrate dual energy X-ray absorptiometry (DXA)-derived bone mineral density and bone size with body size, are inversely associated with hip fracture risk. Our objective was to describe longitudinal trajectories of the strength indices across the menopausal transition.
methodsData came from the Study of Women's Health Across the Nation; participants were pre- or early peri-menopausal, ages 42-53 at baseline, and were followed up for 9.1 ± 1.8 years. Composite indices of femoral neck strength in different failure modes (compression, bending, and impact) were created in 921 women who had three or more hip DXA scans and had definable final menstrual period (FMP) dates. We used mixed effects models to fit piecewise linear growth curves to the baseline-normalized strength indices as a function of time to/after the FMP.
resultsCompression and impact strength indices did not decline until 1 year prior to the FMP, and declined rapidly thereafter, with some slowing of decline 1 year after the FMP. Bending strength index increased slightly until 2 years prior to the FMP, then plateaued, and began to decline at the FMP. Mean decline in strength indices over 10 years was 6.9 % (compression), 2.5 % (bending), and 6.8 % (impact). Women with higher body mass index had larger declines in two of the three indices. Other major modifiers of rates of decline were race/ethnicity and smoking status.
conclusionsFemoral neck strength relative to load declines significantly during the menopausal transition, with declines commencing 1 to 2 years prior to the FMP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.