ArticleCerebellum (London, England)2013
The expression of HDAC1 and HDAC2 during cerebellar cortical development.
Article in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Case report: A newFrontiers in genetics · 2023Article
- Regulation of Central Nervous System Development by Class I Histone Deacetylases.Developmental neuroscience · 2019Review
- METTL3-mediated m6A modification is required for cerebellar development.PLoS biology · 2018Article
- Age-related alterations in histone deacetylase expression in Purkinje neurons of ethanol-fed rats.Brain research · 2017Article
- Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring.Neurotoxicity research · 2017Article
- MBD3 expression and DNA binding patterns are altered in a rat model of temporal lobe epilepsy.Scientific reports · 2016Article
- Article
- Epigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral Deficits.Brain sciences · 2016Review
- Identification of Histone Deacetylase 2 as a Functional Gene for Skeletal Muscle Development in Chickens.Asian-Australasian journal of animal sciences · 2016Article
- Spatiotemporal expression of HDAC2 during the postnatal development of the rat hippocampus.International journal of medical sciences · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Histone deacetylases (HDACs) are epigenetic regulatory proteins that repress gene transcription by changing DNA conformation. The regulation of gene expression through histone deacetylation is an important mechanism for the development of the central nervous system. Although the disruption of the balance in epigenetic gene regulation has been implicated in many CNS developmental abnormalities and diseases, the expression pattern of HDACs in various cell types in the brain during its maturation process has had limited exploration. Therefore, in this study, we investigate the cell type-specific and developmental stage-specific expression pattern of HDAC1 and HDAC2 in the mouse cerebellum. Our experimental results show that the cerebellar progenitors and glial cells express high levels of HDAC1 and low levels of HDAC2. On the other hand, the post-mitotic migrating neuronal cells of the cerebellar cortex show strong HDAC2 and weak HDAC1 expressions. In more differentiated neuronal cells, including Purkinje cells, granule cells, unipolar brush cells, and GABAergic interneurons, we found a consistent expression pattern, high levels of HDAC2 and low levels of HDAC1. Therefore, our data provide support for the potential important roles of HDAC1 in cell proliferation and HDAC2 in migration and differentiation.
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