ArticleMolecular and cellular biochemistry2013
Decreased expression of DNA repair genes (XRCC1, ERCC1, ERCC2, and ERCC4) in squamous intraepithelial lesion and invasive squamous cell carcinoma of the cervix.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Natural resistance to cancers in long-lived mammals: genomic mechanisms and experimental evidence to explain Peto's paradox.Science China. Life sciences · 2025Article
- Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells.Nature communications · 2025Article
- Human Papillomavirus (HPV) Vaccination: Progress, Challenges, and Future Directions in Global Immunization Strategies.Vaccines · 2024Review
- Exploring homologous recombination repair and base excision repair pathway genes for possible diagnostic markers in hematologic malignancies.Molecular genetics and genomics : MGG · 2023Article
- Alteration of the Nucleotide Excision Repair (NER) Pathway in Soft Tissue Sarcoma.International journal of molecular sciences · 2022Article
- The link of ERCC2 rs13181 and ERCC4 rs2276466 polymorphisms with breast cancer in the Bangladeshi population.Molecular biology reports · 2022Article
- Association of ERCC1 rs11615 Polymorphism with the Risk of Cervical Cancer Especially in Chinese Populations: A Meta-Analysis.Journal of oncology · 2022Article
- Perspectives of ERCC1 in early-stage and advanced cervical cancer: From experiments to clinical applications.Frontiers in immunology · 2022Review
- Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction.BMC biology · 2020Article
- The Relationship Between rs3212986C>A Polymorphism and Tumor Stage in Lung Cancer Patients.Cureus · 2019Article
- Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo.Scientific reports · 2019Article
- Human papillomavirus and genome instability: from productive infection to cancer.Clinics (Sao Paulo, Brazil) · 2018Review
- Article
- Association between the XRCC3 Thr241Met Polymorphism and Gastrointestinal Cancer Risk: A Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2016Article
- Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers.Oncotarget · 2016Article
- Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa.Molecular medicine reports · 2016Article
- Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability.Nucleic acids research · 2015Article
- Elucidating the role of excision repair cross-complement group 1 in oral epithelial dysplasia and early invasive squamous cell carcinoma: An immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced DNA repair might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer (CC), to persistent HPV infection, and hence to cervical pre-cancer and cancer. We assessed the variation in baseline expression of base excision repair gene XRCC1 and three nucleotide excision repair genes ERCC1, ERCC2, and ERCC4 and the risk of developing cervical cancer. A hospital-based case-control study was designed with 50 invasive cervical cancer patients, 40 squamous intraepithelial lesions (SIL) patients and 85 controls subjects. RT-qPCR and Western blotting was used to quantitate in vitro the mRNA and protein levels in fresh CC, SIL and normal cervix tissue. The levels of XRCC1, ERCC2, ERCC4, and ERCC1 transcripts and their respective proteins were lower in cervical cancer and SILs as compared to controls (p ≤ 0.001, 0.001, 0.001, and 0.025, respectively). In multivariate logistic regression analysis (adjusting for parity, age at first child birth, use of oral contraceptives, smoking status), low expression of XRCC1, ERCC2, ERCC4, and ERCC1 was associated with a significant increased risk for CC and SIL. Our results suggest that individuals whose expression of XRCC1, ERCC4, ERCC2, and ERCC1 are reduced may be at a higher risk of developing SIL which eventually leads to invasive cervical carcinoma. Moreover, independently also the reduced expression of these genes can directly lead to cervical cancer progression.
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