ArticleDiabetologia2013
Absorption patterns of meals containing complex carbohydrates in type 1 diabetes.
Article in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Do the Types of Dietary Carbohydrate and Protein Affect Postprandial Glycemia in Type 1 Diabetes?Nutrients · 2025Trial
- Trial
- Effect of mulberry fruit extract on glucose fluxes after a wheat porridge meal: a dual isotope study in healthy human subjects.European journal of clinical nutrition · 2023Trial
- Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes.Diabetes, obesity & metabolism · 2018Trial
- Safety, efficacy and glucose turnover of reduced prandial boluses during closed-loop therapy in adolescents with type 1 diabetes: a randomized clinical trial.Diabetes, obesity & metabolism · 2015Trial
- Bolus Estimation--Rethinking the Effect of Meal Fat Content.Diabetes technology & therapeutics · 2015Trial
- Insulin Delivery Hardware: Pumps and Pens.Diabetes technology & therapeutics · 2022Article
- A New Meal Absorption Model for Artificial Pancreas Systems.Journal of diabetes science and technology · 2022Article
- Dual-hormone artificial pancreas for management of type 1 diabetes: Recent progress and future directions.Artificial organs · 2021Review
- Insulin Delivery Hardware: Pumps and Pens.Diabetes technology & therapeutics · 2021Article
- Development platform for artificial pancreas algorithms.PloS one · 2020Article
- A novel natural tracer method to measure complex carbohydrate metabolism.American journal of physiology. Endocrinology and metabolism · 2019Article
- Toward Better Understanding of Insulin Therapy by Translation of a PK-PD Model to Visualize Insulin and Glucose Action Profiles.Journal of clinical pharmacology · 2019Article
- Modelling the effect of insulin on the disposal of meal-attributable glucose in type 1 diabetes.Medical & biological engineering & computing · 2017Article
- Insulin:Carbohydrate Ratio--Part of the Story.Diabetes technology & therapeutics · 2015Article
- Artificial Pancreas Project at Cambridge 2013.Diabetic medicine : a journal of the British Diabetic Association · 2015Review
- Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and β-cell function.American journal of physiology. Endocrinology and metabolism · 2014Article
- Closed-loop artificial pancreas systems: physiological input to enhance next-generation devices.Diabetes care · 2014Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
aims/hypothesisSuccessful postprandial glycaemia management requires understanding of absorption patterns after meals containing variable complex carbohydrates. We studied eight young participants with type 1 diabetes to investigate a large low-glycaemic-load (LG) meal and another eight participants to investigate a high-glycaemic-load (HG) meal matched for carbohydrates (121 g).
methodsOn Visit 1, participants consumed an evening meal. On follow-up Visit 2, a variable-target glucose clamp was performed to reproduce glucose and insulin levels from Visit 1. Adopting stable-label tracer dilution methodology, we measured endogenous glucose production on Visit 2 and subtracted it from total glucose appearance measured on Visit 1 to obtain meal-attributable glucose appearance.
resultsAfter the LG meal, 25%, 50% and 75% of cumulative glucose appearance was at 88 ± 21, 175 ± 39 and 270 ± 54 min (mean ± SD), whereas glucose from the HG meal appeared significantly faster at 56 ± 12, 100 ± 25 and 153 ± 39 min (p < 0.001 to 0.003), and resulted in a 50% higher peak appearance (p < 0.001). Higher apparent bioavailability by 15% (p = 0.037) was observed after the LG meal. We documented a 20 min deceleration of dietary mixed carbohydrates compared with dietary glucose for the HG meal and a twofold deceleration for the LG meal. CONCLUSIONS/
interpretationAbsorption patterns may be influenced by glycaemic load and/or meal composition, affecting optimum prandial insulin dosing in type 1 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.