Evidence map›Paper›PMID 23435750›Full record

ArticleAIDS and behavior2013

Pharmacy and self-report adherence measures to predict virological outcomes for patients on free antiretroviral therapy in Tamil Nadu, India.

James H McMahon, Anand Manoharan, Christine A Wanke, Shoba Mammen, Hepsibah Jose, Thabeetha Malini, Tony Kadavanu, Michael R Jordan, Julian H Elliott, Sharon R Lewin and 1 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Accuracy of measures for antiretroviral adherence in people living with HIV.The Cochrane database of systematic reviews · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

James H McMahonInfectious Diseases Unit, Alfred Hospital, Level 2 Burnet Tower, 85 Commercial Road, Melbourne 3004, Australia. ja.mcmahon@alfred.org.au
Anand Manoharan
Christine A Wanke
Shoba Mammen
Hepsibah Jose
Thabeetha Malini
Tony Kadavanu
Michael R Jordan
Julian H Elliott
Sharon R Lewin
Dilip Mathai

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
Miriam/Brown/Tufts Fogarty AIDS International Training and Research ProgramD43TW000237 · FIC · MIRIAM HOSPITAL · PI CU-UVIN, SUSAN · 1993 to 2014
$10.6M
Emergence of HIV drug resistance: Low-frequency mutations and associated factorsK23AI074423 · NIAID · TUFTS MEDICAL CENTER · PI JORDAN, MICHAEL ROBERT · 2007 to 2011
$667k
FIC NIH HHS 5D43TW000237-15FIC NIH HHS D43 TW000237NIAID NIH HHS 5K23AI074423-04NIAID NIH HHS K23 AI074423NIAID NIH HHS P30 AI042853PHS HHS 1P30A142853-12
6 · The paper itself

Abstract

Over 480,000 individuals receive free antiretroviral therapy (ART) in India yet data associating ART adherence with HIV viral load for populations exclusively receiving free ART are not available. Additionally estimates of adherence using pharmacy data on ART pick-up are not available for any population in India. After 12-months ART we found self-reported estimates of adherence were not associated with HIV viral load. Individuals with <100% adherence using pharmacy data predicted HIV viral load, and estimates combining pharmacy data and self-report were also predictive. Pharmacy adherence measures proved a feasible method to estimate adherence in India and appear more predictive of virological outcomes than self-report. Predictive adherence measures identified in this study warrant further investigation in populations receiving free ART in India to allow for identification of individuals at risk of virological failure and in need of adherence support.

Indexed as

Self ReportViral LoadAdultAnti-HIV AgentsCohort StudiesDrug MonitoringFemaleHIV InfectionsHumansIndiaMaleMedication AdherencePharmacyAnti-HIV Agents

Identifiers

PMID23435750
PMCPMC3674125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.