ArticleScientific reports2013
MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 104 citations in OpenAlex.
- MicroRNA Signatures in Dental Pulp Stem Cells Following Nicotine Exposure.Dentistry journal · 2025Article
- Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated CaMolecular psychiatry · 2023Article
- Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders.Neuronal signaling · 2023Review
- The role of microRNAs in neurobiology and pathophysiology of the hippocampus.Frontiers in molecular neuroscience · 2023Review
- Exosomes-based therapy of stroke, an emerging approach toward recovery.Cell communication and signaling : CCS · 2022Review
- The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p.Biomedicines · 2022Article
- miR-409-3p repressesFrontiers in neuroscience · 2022Article
- An evolutionarily acquired microRNA shapes development of mammalian cortical projections.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124.International journal of molecular sciences · 2020Article
- mRNA and miRNA expression profile reveals the role of miR-31 overexpression in neural stem cell.Scientific reports · 2020Article
- Non-coding RNAs in Ischemic Stroke: Roles in the Neuroinflammation and Cell Death.Neurotoxicity research · 2020Review
- Heroin Abuse and/or HIV Infection Dysregulate Plasma Exosomal miRNAs.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Article
- MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs.Frontiers in cell and developmental biology · 2020Review
- The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke.Metabolic brain disease · 2020Review
- Translating neural stem cells to neurons in the mammalian brain.Cell death and differentiation · 2019Review
- Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina.Scientific reports · 2019Article
- The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia.Cellular and molecular neurobiology · 2019Review
- Effect of let-7a overexpression on the differentiation of conjunctiva mesenchymal stem cells into photoreceptor-like cells.Iranian journal of basic medical sciences · 2019Article
- Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration.Scientific reports · 2019Article
- microRNA Expression Profiles in the Ventral Hippocampus during Pubertal Development and the Impact of Peri-Pubertal Binge Alcohol Exposure.Non-coding RNA · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
MicroRNAs have important functions in the nervous system through post-transcriptional regulation of neurogenesis genes. Here we show that microRNA let-7d, which has been implicated in cocaine addiction and other neurological disorders, targets the neural stem cell regulator TLX. Overexpression of let-7d in vivo reduced neural stem cell proliferation and promoted premature neuronal differentiation and migration, a phenotype similar to those induced by TLX knockdown or overexpression of its negatively-regulated target, microRNA-9. We found a let-7d binding sequence in the tlx 3' UTR and demonstrated that let-7d reduced TLX expression levels in neural stem cells, which in turn, up-regulated miR-9 expression. Moreover, co-expression of let-7d and TLX lacking its 3' UTR in vivo restored neural stem cell proliferation and reversed the premature neuronal differentiation and migration. Therefore, manipulating let-7d and its downstream targets could be a novel strategy to unravel neurogenic signaling pathways and identify potential interventions for relevant neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.