ReviewViruses2013
Intrathecal humoral immunity to encephalitic RNA viruses.
Review in Viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Knowns and unknowns of TiLV-associated neuronal disease.Virulence · 2024Review
- Article
- The repertoire of CSF antiviral antibodies in patients with neuroinflammatory diseases.Science advances · 2023Article
- B cells going viral in the CNS: Dynamics, complexities, and functions of B cells responding to viral encephalitis.Immunological reviews · 2022Review
- Infection in the Developing Brain: The Role of Unique Systemic Immune Vulnerabilities.Frontiers in neurology · 2021Review
- Acute RNA Viral Encephalomyelitis and the Role of Antibodies in the Central Nervous System.Viruses · 2020Review
- How to detect and track chronic neurologic sequelae of COVID-19? Use of auditory brainstem responses and neuroimaging for long-term patient follow-up.Brain, behavior, & immunity - health · 2020Review
- Clinical utility of a molecular signature in inflammatory demyelinating disease.Neurology(R) neuroimmunology & neuroinflammation · 2019Article
- Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases.PLoS pathogens · 2018Article
- Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.Journal of virology · 2017Article
- Keeping it in check: chronic viral infection and antiviral immunity in the brain.Nature reviews. Neuroscience · 2016Review
- Immune Surveillance of the CNS following Infection and Injury.Trends in immunology · 2015Review
- Article
- Article
- IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients.Human vaccines & immunotherapeutics · 2014Review
- Immune responses to non-tumor antigens in the central nervous system.Frontiers in oncology · 2014Review
- Probable Neuropsychological and Cognitive Complications Due to Cytokine Storm in Patients With COVID-19.Basic and clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The nervous system is the target for acute encephalitic viral infections, as well as a reservoir for persisting viruses. Intrathecal antibody (Ab) synthesis is well documented in humans afflicted by infections associated with neurological complications, as well as the demyelinating disease, multiple sclerosis. This review focuses on the origin, recruitment, maintenance, and biological relevance of Ab-secreting cells (ASC) found in the central nervous system (CNS) following experimental neurotropic RNA virus infections. We will summarize evidence for a highly dynamic, evolving humoral response characterized by temporal alterations in B cell subsets, proliferation, and differentiation. Overall local Ab plays a beneficial role via complement-independent control of virus replication, although cross or self-reactive Ab to CNS antigens may contribute to immune-mediated pathogenesis during some infections. Importantly, protective Ab exert anti-viral activity not only by direct neutralization, but also by binding to cell surface-expressed viral glycoproteins. Ab engagement of viral glycoproteins blocks budding and mediates intracellular signaling leading to restored homeostatic and innate functions. The sustained Ab production by local ASC, as well as chemokines and cytokines associated with ASC recruitment and retention, are highlighted as critical components of immune control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.