ArticleThe Analyst2013
Blood and breath levels of selected volatile organic compounds in healthy volunteers.
Article in The Analyst, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- Comparing patterns of volatile organic compounds exhaled in breath after consumption of two infant formulae with a different lipid structure: a randomized trial.Scientific reports · 2019Trial
- Diurnal variation in expired breath volatiles in malaria-infected and healthy volunteers.Journal of breath research · 2018Trial
- Blood and breath profiles of volatile organic compounds in patients with end-stage renal disease.BMC nephrology · 2014Trial
- A novel substrate for CYP3A4 phenotyping: in vitro biotransformation of hubamine into butanone.Analytical and bioanalytical chemistry · 2026Article
- Soft ionization by chemical reaction in transfer-high-resolution mass spectrometry for clinical exhaled breath profiling.Analytical and bioanalytical chemistry · 2026Article
- Volatile Organic Compounds (VOCs) in Neurodegenerative Diseases (NDDs): Diagnostic Potential and Analytical Approaches.Molecules (Basel, Switzerland) · 2025Review
- Oral Microbiota Taxa and Pri-miRNA Expression in Bipolar Disorder: A Case-Control Study.Biomolecules · 2025Article
- Breath Insights: Advancing Lung Cancer Early-Stage Detection Through AI Algorithms in Non-Invasive VOC Profiling Trials.Cancers · 2025Article
- Article
- Gas-chromatographic headspace analysis in human biomonitoring (headspace-gas chromatography): Biomonitoring Methods, Conceptual Topics - Translation of the German version from 2025.The MAK collection for occupational health and safety · 2025Article
- Altered oxidative stress and antioxidant biomarkers concentrations in pregnant individuals exposed to oil and gas sites in Northeastern British Columbia.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Breath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography-Mass Spectrometry Analysis.International journal of molecular sciences · 2024Article
- Headspace Solid-Phase Micro-Extraction Method Optimization and Evaluation for the Volatile Compound Extraction of Bronchoalveolar Lung Lavage Fluid Samples.Separations · 2024Article
- Breathomics Detect the Cardiovascular Disease: Delusion or Dilution of the Metabolomic Signature.Current cardiology reviews · 2024Review
- Nanoscale designing of metal organic framework moieties as efficient tools for environmental decontamination.Nanoscale advances · 2023Review
- Application of untargeted volatile profiling in inflammatory bowel disease research.Analytical and bioanalytical chemistry · 2023Article
- Smelling the Disease: Diagnostic Potential of Breath Analysis.Molecular diagnosis & therapy · 2023Review
- HExpPredict:Environmental health perspectives · 2023Article
- Unraveling the potential of breath and sweat VOC capture devices for human disease detection: a systematic-like review of canine olfaction and GC-MS analysis.Frontiers in chemistry · 2023Review
- Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Gas chromatography with mass spectrometric detection (GC-MS) was used to identify and quantify volatile organic compounds in the blood and breath of healthy individuals. Blood and breath volatiles were pre-concentrated using headspace solid phase micro-extraction (HS-SPME) and needle trap devices (NTDs), respectively. The study involved a group of 28 healthy test subjects and resulted in the quantification of a total of 74 compounds in both types of samples. The concentrations of the species under study varied between 0.01 and 6700 nmol L(-1) in blood and between 0.02 and 2500 ppb in exhaled air. Limits of detection (LOD) ranged from 0.01 to 270 nmol L(-1) for blood compounds and from 0.01 to 0.7 ppb for breath species. Relative standard deviations for both measurement regimes varied from 1.5 to 14%. The predominant chemical classes among the compounds quantified were hydrocarbons (24), ketones (10), terpenes (8), heterocyclic compounds (7) and aromatic compounds (7). Twelve analytes were found to be highly present in both blood and exhaled air (with incidence rates higher than 80%) and for 32 species significant differences (Wilcoxon signed-rank test) between room air and exhaled breath were observed. By comparing blood, room air and breath levels in parallel, a tentative classification of volatiles into endogenous and exogenous compounds can be achieved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.