ArticlePlant signaling & behavior2013
Arabidopsis scaffold protein RACK1A interacts with diverse environmental stress and photosynthesis related proteins.
Article in Plant signaling & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Receptor for Activated C Kinase1B (RACK1B) Delays Salinity-Induced Senescence in Rice Leaves by Regulating Chlorophyll Degradation.Plants (Basel, Switzerland) · 2023Article
- Receptor for Activated C Kinase1B (OsRACK1B) Impairs Fertility in Rice through NADPH-Dependent HInternational journal of molecular sciences · 2022Article
- Protein-protein interactions in plant antioxidant defense.Frontiers in plant science · 2022Review
- A Conserved Long Intergenic Non-coding RNA Containing snoRNA Sequences,Frontiers in plant science · 2022Article
- Small compounds targeting tyrosine phosphorylation of Scaffold Protein Receptor for Activated C Kinase1A (RACK1A) regulate auxin mediated lateral root development inPlant signaling & behavior · 2021Article
- Genome-wide transcriptome reveals mechanisms underlying Rlm1-mediated blackleg resistance on canola.Scientific reports · 2021Article
- Ribosomal protein QM/RPL10 positively regulates defence and protein translation mechanisms during nonhost disease resistance.Molecular plant pathology · 2020Article
- Drought resistance is mediated by divergent strategies in closely related Brassicaceae.The New phytologist · 2019Article
- Host targeted antiviral (HTA): functional inhibitor compounds of scaffold protein RACK1 inhibit herpes simplex virus proliferation.Oncotarget · 2019Article
- Ribosome profiles and riboproteomes of healthy and Potato virus A- and Agrobacterium-infected Nicotiana benthamiana plants.Molecular plant pathology · 2019Article
- miR393s regulate salt stress response pathway in Arabidopsis thaliana through scaffold protein RACK1A mediated ABA signaling pathways.Plant signaling & behavior · 2019Article
- OsRACK1A, encodes a circadian clock-regulated WD40 protein, negatively affect salt tolerance in rice.Rice (New York, N.Y.) · 2018Article
- The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense.Scientific reports · 2018Article
- Integrated proteomic analysis of Brachypodium distachyon roots and leaves reveals a synergistic network in the response to drought stress and recovery.Scientific reports · 2017Article
- A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering Mutations.G3 (Bethesda, Md.) · 2016Article
- Tyrosine Phosphorylation Based Homo-dimerization of Arabidopsis RACK1A Proteins Regulates Oxidative Stress Signaling Pathways in Yeast.Frontiers in plant science · 2016Article
- AealRACK1 expression and localization in response to stress in C6/36 HT mosquito cells.Journal of proteomics · 2015Article
- Arabidopsis receptor of activated C kinase1 phosphorylation by WITH NO LYSINE8 KINASE.Plant physiology · 2015Article
- The Receptor for Activated C Kinase in Plant Signaling: Tale of a Promiscuous Little Molecule.Frontiers in plant science · 2015Review
- Phosphorylation of RACK1 in plants.Plant signaling & behavior · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scaffold proteins are known to regulate important cellular processes by interacting with multiple proteins to modulate molecular responses. RACK1 (Receptor for Activated C Kinase 1) is a WD-40 type scaffold protein, conserved in eukaryotes, from Chlamydymonas to plants and humans, expresses ubiquitously and plays regulatory roles in diverse signal transduction and stress response pathways. Here we present the use of Arabidopsis RACK1A, the predominant isoform of a 3-member family, as a bait to screen a split-ubiquitin based cDNA library. In total 97 proteins from dehydration, salt stress, ribosomal and photosynthesis pathways are found to potentially interact with RACK1A. False positive interactions were eliminated following extensive selection based growth potentials. Confirmation of a sub-set of selected interactions is demonstrated through the co-transformation with individual plasmid containing cDNA and the respective bait. Interaction of diverse proteins points to a regulatory role of RACK1A in the cross-talk between signaling pathways. Promoter analysis of the stress and photosynthetic pathway genes revealed conserved transcription factor binding sites. RACK1A is known to be a multifunctional protein and the current identification of potential interacting proteins and future in vivo elucidations of the physiological basis of such interactions will shed light on the possible molecular mechanisms that RACK1A uses to regulate diverse signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.