Evidence map›Paper›PMID 23435159›Full record

Trial reportDiabetes care2013

Randomized study comparing a Basal-bolus with a basal plus correction insulin regimen for the hospital management of medical and surgical patients with type 2 diabetes: basal plus trial.

Guillermo E Umpierrez, Dawn Smiley, Kathie Hermayer, Amna Khan, Darin E Olson, Christopher Newton, Sol Jacobs, Monica Rizzo, Limin Peng, David Reyes and 6 more

5 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 95 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 9 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00979628 phase4completednot on this map

Basal Bolus Versus Basal Insulin Regimen for the Treatment of Hospitalized Patients With Type 2 Diabetes Mellitus

TypeinterventionalSponsorGuillermo Umpierrez, MDRan2010 to 2012Enrolled375ConditionsType 2 Diabetes, HyperglycemiaArmssliding scale regular insulin (SSRI), Basal Bolus, Basal Plus
NCT03350984 phase4completednot on this mapstarted 2017, after this paper: background citation

Insulin Scheme for Glycemic Control in Non-critical Hospitalized Patients With Type 2 Diabetes in the Context of a Health System in Mexico.

TypeinterventionalSponsorUniversidad de GuanajuatoRan2017 to 2018Enrolled75ConditionsType 2 Diabetes MellitusArmsNPH insulin, Glargine and Lispro insulin
NCT05036876 nacompletednot on this mapstarted 2021, after this paper: background citation

Insulin Degludec Versus Glargine U300 for the Management of Hospitalized Patients With Type 2 Diabetes: Randomized Controlled Trial

TypeinterventionalSponsorMedanta, The Medicity, IndiaRan2021 to 2022Enrolled220ConditionsType 2 DiabetesArmsDegludec, Glargine U300
NCT05752929 phase4completednot on this mapstarted 2016, after this paper: background citation

Comparison of 2 Hyperglycemia-correction Scales in Hospitalized Patients in an Institution in Bogotá, Colombia

TypeinterventionalSponsorHospital Universitario Clinica San RafaelRan2016 to 2019Enrolled116ConditionsDiabete Type 2, HyperglycemiaArmsInsulin, insulin
NCT06206525 nacompletednot on this mapstarted 2024, after this paper: background citation

Feasibility Trial Using an Insulin Dosing Calculator for Patients With Type 2 Diabetes Mellitus on Hospital Admission

TypeinterventionalSponsorUniversity of WashingtonRan2024 to 2025Enrolled38ConditionsDiabetes Mellitus, Type 2ArmsInitial insulin dosing calculator
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 9 syntheses or guidelines pooled it, 217 citations in OpenAlex.

  1. Pooled it
  2. [Hospital diabetes management (Update 2026)].Wiener klinische Wochenschrift · 2026
    Guideline
  3. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  4. Pooled it
  5. Guideline
  6. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019
    Guideline
  7. Pooled it
  8. Pooled it
  9. Enhanced Recovery After Surgery (ERASWorld journal of surgery · 2017
    Pooled it
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Guillermo E UmpierrezDepartment of Medicine, Division of Endocrinology, Emory University, Atlanta, Georgia, USA. geumpie@emory.edu
Dawn Smiley
Kathie Hermayer
Amna Khan
Darin E Olson
Christopher Newton
Sol Jacobs
Monica Rizzo
Limin Peng
David Reyes
Ingrid Pinzon
Maria Eugenia Fereira
Vicky Hunt
Ashwini Gore
Marcos T Toyoshima
Vivian A Fonseca
Emory University · USMedical University of South Carolina · USTulane Medical Center · USVeterans Health Administration · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
NCATS NIH HHS UL1 TR000454NCRR NIH HHS UL1 RR025008NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

objectiveEffective and easily implemented insulin regimens are needed to facilitate hospital glycemic control in general medical and surgical patients with type 2 diabetes (T2D). RESEARCH DESIGN AND

methodsThis multicenter trial randomized 375 patients with T2D treated with diet, oral antidiabetic agents, or low-dose insulin (≤ 0.4 units/kg/day) to receive a basal-bolus regimen with glargine once daily and glulisine before meals, a basal plus regimen with glargine once daily and supplemental doses of glulisine, and sliding scale regular insulin (SSI).

resultsImprovement in mean daily blood glucose (BG) after the first day of therapy was similar between basal-bolus and basal plus groups (P = 0.16), and both regimens resulted in a lower mean daily BG than did SSI (P = 0.04). In addition, treatment with basal-bolus and basal plus regimens resulted in less treatment failure (defined as >2 consecutive BG >240 mg/dL or a mean daily BG >240 mg/dL) than did treatment with SSI (0 vs. 2 vs. 19%, respectively; P < 0.001). A BG <70 mg/dL occurred in 16% of patients in the basal-bolus group, 13% in the basal plus group, and 3% in the SSI group (P = 0.02). There was no difference among the groups in the frequency of severe hypoglycemia (<40 mg/dL; P = 0.76).

conclusionsThe use of a basal plus regimen with glargine once daily plus corrective doses with glulisine insulin before meals resulted in glycemic control similar to a standard basal-bolus regimen. The basal plus approach is an effective alternative to the use of a basal-bolus regimen in general medical and surgical patients with T2D.

Indexed as

HospitalizationSurgical Procedures, OperativeAdultAgedBlood GlucoseDiabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsInsulinInsulin GlargineInsulin, Long-ActingMaleMealsMiddle AgedTreatment OutcomeBlood GlucoseHypoglycemic AgentsInsulinInsulin Glargineinsulin glulisineInsulin, Long-Acting

Identifiers

PMID23435159
PMCPMC3714500
OpenAlexW2113123801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.