ArticleDiabetes2013
Systemic free fatty acid disposal into very low-density lipoprotein triglycerides.
Article in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Effectiveness of moderate-to-low intensity exercise snacks on glucose and lipid metabolism in sedentary adults: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Subcutaneous adipose tissue free fatty acid uptake measured using positron emission tomography and adipose biopsies in humans.American journal of physiology. Endocrinology and metabolism · 2019Trial
- Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis.The American journal of clinical nutrition · 2015Trial
- Systemic delivery of estradiol, but not testosterone or progesterone, alters very low density lipoprotein-triglyceride kinetics in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2014Trial
- HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome.Antioxidants (Basel, Switzerland) · 2025Review
- Association between atherogenic index of plasma and hypertension: exploring the mediating role of body mass index in a Chinese population aged ≥ 45 years.Frontiers in public health · 2025Article
- Article
- The Protective Effect ofNutrients · 2020Article
- Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and FibrosisAntioxidants (Basel, Switzerland) · 2019Article
- Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis.Clinical and molecular hepatology · 2018Article
- Changes in fatty acid composition in tissue and serum of obese cats fed a high fat diet.BMC veterinary research · 2015Article
- Free fatty acid uptake in humans with CD36 deficiency.Diabetes · 2014Article
- Fine-tuned iron availability is essential to achieve optimal adipocyte differentiation and mitochondrial biogenesis.Diabetologia · 2014Article
- Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.Gastroenterology · 2014Article
- The role of Fatty Acid oxidation in the metabolic reprograming of activated t-cells.Frontiers in immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We measured the incorporation of systemic free fatty acids (FFA) into circulating very low-density lipoprotein triglycerides (VLDL-TGs) under postabsorptive, postprandial, and walking conditions in humans. Fifty-five men and 85 premenopausal women with BMI 18-24 (lean) and 27-36 kg/m(2) (overweight/obese) received an intravenous bolus injection of [1,1,2,3,3-(2)H5]glycerol (to measure VLDL-TG kinetics) and either [1-(14)C]palmitate or [9,10-(3)H]palmitate to determine the proportion of systemic FFA that is converted to VLDL-TG. Experiments started at 0630 h after a 12-h overnight fast. In the postabsorptive protocol, participants rested and remained fasted until 1330 h. In the postprandial protocol, volunteers ingested frequent portions of a fat-free smoothie. In the walking protocol, participants walked on a treadmill for 5.5 h at ∼3× resting energy expenditure. Approximately 7% of circulating FFA was converted into VLDL-TG. VLDL-TG secretion rates (SRs) were not statistically different among protocols. Visceral fat mass was the only independent predictor of VLDL-TG secretion, explaining 33-57% of the variance. The small proportion of systemic FFA that is converted to VLDL-TG can confound the expected relationship between plasma FFA concentration and VLDL-TG SRs. Regulation of VLDL-TG secretion is complex in that, despite a broad spectrum of physiological FFA concentrations, VLDL-TG SRs did not vary based on different acute substrate availability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.