ArticleJournal of molecular biology2013
All repeats are not equal: a module-based approach to guide repeat protein design.
Article in Journal of molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A Generalized AI View of Tricopeptide Repeats: What's in a Name.International journal of molecular sciences · 2025Review
- Diversity and features of proteins with structural repeats.Biophysical reviews · 2023Review
- An Analytical Review of the Structural Features of Pentatricopeptide Repeats: Strategic Amino Acids, Repeat Arrangements and Superhelical Architecture.International journal of molecular sciences · 2021Review
- Evolution of Protein Structure and Stability in Global Warming.International journal of molecular sciences · 2020Review
- The Nature and Arrangement of Pentatricopeptide Domains and the Linker Sequences Between Them.Bioinformatics and biology insights · 2020Article
- TPR-containing proteins control protein organization and homeostasis for the endoplasmic reticulum.Critical reviews in biochemistry and molecular biology · 2019Review
- Protein Tetratricopeptide Repeat and the Companion Non-tetratricopeptide Repeat Helices: Bioinformatic Analysis of Interhelical Interactions.Bioinformatics and biology insights · 2019Article
- Induction of Recombinant Lectin Expression by an Artificially Constructed Tandem Repeat Structure: A Case Study UsingBiomolecules · 2018Article
- On the role, ecology, phylogeny, and structure of dual-family immunophilins.Cell stress & chaperones · 2017Article
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- The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats.Nucleic acids research · 2016Article
- Tandem Repeats in Proteins: Prediction Algorithms and Biological Role.Frontiers in bioengineering and biotechnology · 2015Review
- Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge.Current opinion in structural biology · 2014Review
- NextGen protein design.Biochemical Society transactions · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Repeat proteins composed of tandem arrays of a short structural motif often mediate protein-protein interactions. Past efforts to design repeat protein-based molecular recognition tools have focused on the creation of templates from the consensus of individual repeats, regardless of their natural context. Such an approach assumes that all repeats are essentially equivalent. In this study, we present the results of a "module-based" approach in which modules composed of tandem repeats are aligned to identify repeat-specific features. Using this approach to analyze tetratricopeptide repeat modules that contain three tandem repeats (3TPRs), we identify two classes of 3TPR modules with distinct structural signatures that are correlated with different sets of functional residues. Our analyses also reveal a high degree of correlation between positions across the entire ligand-binding surface, indicative of a coordinated, coevolving binding surface. Extension of our analyses to different repeat protein modules reveals more examples of repeat-specific features, especially in armadillo repeat modules. In summary, the module-based analyses that we present effectively capture key repeat-specific features that will be important to include in future repeat protein design templates.
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Registered trials
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