ArticleInternational journal of molecular sciences2013
Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 1 of them a synthesis that pooled it.
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Who cites it
183 citing papers in PubMed, 1 synthesis or guideline pooled it, 497 citations in OpenAlex.
- Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2.Molecules (Basel, Switzerland) · 2020Pooled it
- Integrated metabolomics and network pharmacology to decipher habitat-driven metabolic diversity andFood chemistry: X · 2026Article
- Integrated Metabolomics and Selection Signal Analysis Provide Insights Into the Selection for Flavonol Biosynthesis Associated With Lettuce Quality Improvement.Plant biotechnology journal · 2026Article
- Ruthenium-Catalyzed C-H Alkenylation of Flavones with Alkenes: Chemoselective Synthesis and Mechanistic Insights from DFT Studies.The Journal of organic chemistry · 2026Article
- Chitooligosaccharide Seed Priming Enhances Photosynthetic Efficiency in Pea (International journal of molecular sciences · 2026Article
- Brazilian Mining Dam Collapse: Molecular Networking-Guided Metabolomics Reveals Species-Specific Plant Detox.ACS omega · 2026Article
- Comparative Metabolomics and Transcriptomics Analysis ofMolecules (Basel, Switzerland) · 2026Article
- Article
- Metabolo-Transcriptomics Analyses Reveal Alfalfa Adaptation to Combined Saline-Alkali and Low-Temperature Stress in the Field.Plant biotechnology journal · 2026Article
- Host-dependent variations in antioxidant activity, metabolic profile, and phenolic content of the parasitic plant Phoradendron nervosum Oliv.Scientific reports · 2026Article
- Stage-specific metabolic divergence in flavonoid biosynthesis correlates with embryogenic capacity in rubber tree (Frontiers in plant science · 2026Article
- From metabolomics to molecular docking: Unveiling the antioxidant potential of EcuadorianFood chemistry: X · 2026Article
- A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming.Frontiers in plant science · 2026Review
- Effects of dietary supplementation with fenugreek oil on growth, physiology, and resistance toOpen veterinary journal · 2025Article
- Integrated metabolomic and transcriptomic analyses identify MYB genes regulating key metabolites and agronomic traits in upland cotton Gossypium hirsutum.Nature genetics · 2025Article
- The Novel Flax Cultivar Silesia Shows High Morphogenetic Capacity in Tissue Cultures.International journal of molecular sciences · 2025Article
- Review
- Tangeretin induces apoptosis and cell cycle arrest in thyroid cancer cells.Toxicological research · 2025Article
- Bi-functional transcription factor SlbHLH95 regulates fruits flavonoid metabolism and grey mould resistance in tomato.Plant biotechnology journal · 2025Article
- Addition of polyphenolic extracts of Myrtus communis and Arbutus unedo fruits to whey: valorization of a common dairy waste product as a functional food.Journal of the science of food and agriculture · 2025Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenylpropanoids, particularly flavonoids have been recently suggested as playing primary antioxidant functions in the responses of plants to a wide range of abiotic stresses. Furthermore, flavonoids are effective endogenous regulators of auxin movement, thus behaving as developmental regulators. Flavonoids are capable of controlling the development of individual organs and the whole-plant; and, hence, to contribute to stress-induced morphogenic responses of plants. The significance of flavonoids as scavengers of reactive oxygen species (ROS) in humans has been recently questioned, based on the observation that the flavonoid concentration in plasma and most tissues is too low to effectively reduce ROS. Instead, flavonoids may play key roles as signaling molecules in mammals, through their ability to interact with a wide range of protein kinases, including mitogen-activated protein kinases (MAPK), that supersede key steps of cell growth and differentiation. Here we discuss about the relative significance of flavonoids as reducing agents and signaling molecules in plants and humans. We show that structural features conferring ROS-scavenger ability to flavonoids are also required to effectively control developmental processes in eukaryotic cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.