ArticleDevelopmental and comparative immunology2013
Sockeye salmon retain immunoglobulin-secreting plasma cells throughout their spawning journey and post-spawning.
Article in Developmental and comparative immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- An Update on the Evolutionary History of Bregs.Genes · 2022Review
- The intersection of stress, sex and immunity in fishes.Immunogenetics · 2021Review
- Transient increase in abundance of B lineage but not myeloid-lineage cells in anterior kidney of sockeye salmon during return migration to the natal grounds.Fish & shellfish immunology · 2020Article
- Outcome of within-host competition demonstrates that parasite virulence doesn't equal success in a myxozoan model system.International journal for parasitology. Parasites and wildlife · 2019Article
- Melanomacrophages and melanomacrophage centres inCentral-European journal of immunology · 2019Review
- Innate immune cell signatures in a BCWD-Resistant line of rainbow trout before and after in vivo challenge with Flavobacterium psychrophilum.Developmental and comparative immunology · 2019Article
- Specific humoral immunity inCentral-European journal of immunology · 2018Review
- A BCWD-resistant line of rainbow trout exhibits higher abundance of IgTDevelopmental and comparative immunology · 2017Article
- Infectious hematopoietic necrosis virus (IHNV) persistence in Sockeye Salmon: influence on brain transcriptome and subsequent response to the viral mimic poly(I:C).BMC genomics · 2015Article
- Insight from molecular, pathological, and immunohistochemical studies on cellular and humoral mechanisms responsible for vaccine-induced protection of rainbow trout against Yersinia ruckeri.Clinical and vaccine immunology : CVI · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Antibody-producing plasma cells are a major source of protective immunity in vertebrates, including salmon. During the spawning phase, salmon undergo drastic, hormonally driven changes in their physiology, including elevated levels of cortisol, which are known to suppress the immune system. As adult fish need to survive their long journey to the spawning grounds, we hypothesized that humoral immunity, in the form of IgM-secreting plasma cells, remains functional until post-spawning. This was investigated by measuring changes in membrane and secreted immunoglobulin heavy chain mu and Pax5 transcripts in spleen and kidney from migrating sockeye salmon, using real-time qPCR. As an additional measurement, the abundance of developing B, mature B, and plasma cells was determined in spawning fish, using flow cytometry. Immune tissue samples were collected from fish from the Kenai River drainage and Main Bay, Prince William Sound. Our results reveal that spawning fish express high levels of secreted heavy chain mu transcripts in their spleen and anterior kidney throughout the spawning journey. Furthermore, we show that IgM-secreting PCs (HCmu++/Pax5-) remain abundant in anterior kidney and spleen of post-spawning sockeye salmon, with a concomitant loss in developing B cells (HCmu-/Pax5+). This suggests that successful spawners retain their PCs throughout the spawning journey and post-spawning.
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Registered trials
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