ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2013
Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 166 citations in OpenAlex.
- Distinct impacts of sodium channel blockers on the strength-duration properties of human motor cortex neurons.Epilepsia · 2025Trial
- Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Efficient and reliable characterization of the corticospinal system using transcranial magnetic stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2014Trial
- TMS of primary motor cortex with a biphasic pulse activates two independent sets of excitable neurones.Brain stimulationTrial
- Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome.Brain stimulationTrial
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Precision in Delivery, Variability in Response: A Multiscale Mechanistic Framework for Neuronavigated Transcranial Magnetic Stimulation.Brain sciences · 2026Review
- Histologically Informed Multiscale Modeling of the Neuronal Elements Activated by TMS.bioRxiv : the preprint server for biology · 2026Article
- Stochastic Approximator of Motor Threshold (SAMT) for Transcranial Magnetic Stimulation: Online Software and Its Performance in Clinical Studies.Transcranial magnetic stimulation (2024) · 2026Article
- Cellular Mechanisms of Transcranial Magnetic Stimulation in Climbing Fibers and Purkinje Neurons in the Cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Article
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- Axonal structure-function relationships across experimental modalities.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Persistent adaptations in sensorimotor interneuron circuits in the motor cortex with a history of sport-related concussion.Experimental brain research · 2024Article
- Abnormalities of cortical stimulation strength-duration time constant in amyotrophic lateral sclerosis.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Design and Validation of Miniaturized Repetitive Transcranial Magnetic Stimulation (rTMS) Head Coils.Sensors (Basel, Switzerland) · 2024Article
- Electric-field-based dosing for TMS.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Transcranial magnetic stimulation input-output curve slope differences suggest variation in recruitment across muscle representations in primary motor cortex.Frontiers in human neuroscience · 2024Article
- High inductance magnetic-core coils have enhanced efficiency in inducing suprathreshold motor response in rats.Physics in medicine and biology · 2023Article
- Three novel methods for determining motor threshold with transcranial magnetic stimulation outperform conventional procedures.Journal of neural engineering · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo demonstrate the use of a novel controllable pulse parameter TMS (cTMS) device to characterize human corticospinal tract physiology.
methodsMotor threshold and input-output (IO) curve of right first dorsal interosseus were determined in 26 and 12 healthy volunteers, respectively, at pulse widths of 30, 60, and 120 μs using a custom-built cTMS device. Strength-duration curve rheobase and time constant were estimated from the motor thresholds. IO slope was estimated from sigmoid functions fitted to the IO data.
resultsAll procedures were well tolerated with no seizures or other serious adverse events. Increasing pulse width decreased the motor threshold and increased the pulse energy and IO slope. The average strength-duration curve time constant is estimated to be 196 μs, 95% CI [181 μs, 210 μs]. IO slope is inversely correlated with motor threshold both across and within pulse width. A simple quantitative model explains these dependencies.
conclusionsOur strength-duration time constant estimate compares well to published values and may be more accurate given increased sample size and enhanced methodology. Multiplying the IO slope by the motor threshold may provide a sensitive measure of individual differences in corticospinal tract physiology. SIGNIFICANCE: Pulse parameter control offered by cTMS provides enhanced flexibility that can contribute novel insights in TMS studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.