ArticleBiological psychiatry2013
Posttraumatic stress disorder and impaired autonomic modulation in male twins.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 103 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cereset Research Exploratory Study
Cereset Research To Reduce Stress In Healthcare Workers In The Time Of COVID-19
Randomized Controlled Pilot Trial of Cereset Research For Chronic Nausea
Who cites it
103 citing papers in PubMed, 2 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Autonomic dysfunction in posttraumatic stress disorder indexed by heart rate variability: a meta-analysis.Psychological medicine · 2020Pooled it
- Relationships Between Heart Rate Variability, Occupational Performance, and Fitness for Tactical Personnel: A Systematic Review.Frontiers in public health · 2020Pooled it
- Effect of cognitive processing therapy on markers of cardiovascular risk in posttraumatic stress disorder patients: A randomized clinical trial.Journal of psychosomatic research · 2023Trial
- Burden and Heart Rate Variability in Bipolar Disorder Family Caregivers.Western journal of nursing research · 2022Trial
- Angiotensin involvement in trauma processing-exploring candidate neurocognitive mechanisms of preventing post-traumatic stress symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Successful use of closed-loop allostatic neurotechnology for post-traumatic stress symptoms in military personnel: self-reported and autonomic improvements.Military Medical Research · 2017Trial
- Mitigating the effect of non-stationarity in spectral analysis-an application to neonate heart rate analysis.Computers in biology and medicine · 2013Trial
- Quantifying acute physiological biomarkers of transcutaneous cervical vagal nerve stimulation in the context of psychological stress.Brain stimulationTrial
- Mental stress as a trigger of cardiovascular events: A narrative review.European journal of clinical investigation · 2026Review
- Heart rate variability, ECG minor changes, and HRV-ECG coupling associated with an adjunctive structured breathing-meditation protocol in combat-exposed military personnel.Frontiers in network physiology · 2026Article
- Effects of a neo-functional psychotherapeutic approach on post-traumatic stress disorder following spontaneous coronary artery dissection: a case report.Frontiers in cardiovascular medicine · 2026Article
- Post-Traumatic Stress Disorder (PTSD) and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Chilling and Blurring Negative Memories: An Experimental Memory Training Study.Basic and clinical neuroscience · 2025Article
- Mental health disorders and their impact on cardiovascular health disparities.The Lancet regional health. Europe · 2025Review
- Association of stress-induced autonomic dysfunction with heart failure in individuals with stable coronary artery disease.International journal of cardiology. Heart & vasculature · 2025Article
- Parasympathetic response in women with coronary vascular dysfunction during mental stress compared to those with non-cardiac chest pain and reference controls.International journal of cardiology. Heart & vasculature · 2025Article
- Posttraumatic Stress Disorder and the Risk of Heart Failure Hospitalizations Among Individuals With Coronary Artery Disease.Circulation. Cardiovascular quality and outcomes · 2024Article
- Autonomic reactivity to mental stress is associated with cardiovascular mortality.European heart journal open · 2024Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Quantifying Posttraumatic Stress Disorder Symptoms During Traumatic Memories Using Interpretable Markers of Respiratory Variability.IEEE journal of biomedical and health informatics · 2024Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPosttraumatic stress disorder (PTSD) has been linked to increased morbidity. An inflexibility of the autonomic nervous system might be the underlying mechanism. We aimed to assess whether PTSD and combat trauma exposure are associated with lower heart rate variability (HRV), a measure of autonomic function and a predictor of death.
methodsWe measured HRV by power spectral analysis on 24-hour ambulatory electrocardiogram in 459 middle-aged veteran male twins. Combat trauma was assessed with the combat exposure scale, and current and remitted PTSD was assessed with the Structured Clinical Interview for Psychiatry Disorders. Mixed-effects regression models were used to test associations of PTSD and HRV between and within twin pairs.
resultsOf all twins, 211 had combat exposure, 31 had current PTSD, and 43 had remitted PTSD. Current PTSD was inversely associated with very-low-frequency and low-frequency HRV both in individual twins and within 20 pairs discordant for current PTSD. Twins with current PTSD had a 49% lower low-frequency HRV than their brothers without PTSD (p<.001). Remitted PTSD was not associated with HRV. Results were robust to adjustment for depression and other risk factors. Combat exposure was inversely associated with most HRV frequencies, but this association mostly diminished after adjustment for current PTSD.
conclusionIn middle-aged veteran men, combat exposure and current PTSD are associated with measures of autonomic inflexibility previously shown to have prognostic significance. The negative health impact of combat exposure on autonomic function is mediated largely through PTSD and might reverse with remission of PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.