ArticleDental materials : official publication of the Academy of Dental Materials2013
Enhancement in dentin collagen's biological stability after proanthocyanidins treatment in clinically relevant time periods.
Article in Dental materials : official publication of the Academy of Dental Materials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Preventive and Therapeutic Effects of Plant-Derived Compounds on Tooth Erosion: A Systematic Review and Meta-Analysis of In Situ and In Vitro Studies.Clinical and experimental dental research · 2025Pooled it
- Pooled it
- Proanthocyanidins rapidly stabilize the demineralized dentin layer.Journal of dental research · 2013Trial
- Saturated anacardic acid preserves root dentin collagen under cariogenic challenge.Clinical oral investigations · 2026Article
- Electrospun Fibers EncapsulatingMolecules (Basel, Switzerland) · 2026Article
- Biomodification of dentin collagen with hydroalcoholic propolis extract: Impact on resin-dentin adhesion.European journal of oral sciences · 2026Article
- Comparison of microtensile bond strength of prepared teeth treated with proanthocyanidin, Camellia sinensis - Polyphenols, and metal crowns luted with resin-modified glass ionomer cement: An in vitro study.Journal of Indian Prosthodontic Society · 2024Article
- Preliminary Evaluation of Bioactive Collagen-Polyphenol Surface Nanolayers on Titanium Implants: An X-ray Photoelectron Spectroscopy and Bone Implant Study.Journal of functional biomaterials · 2024Article
- Theaflavin -3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen.Frontiers in bioengineering and biotechnology · 2024Article
- Does the pH of the grape seed extract interfere in the biomodification capacity of dentin collagen?Brazilian dental journal · 2024Article
- Fucosterol and Fucoxanthin Enhance Dentin Collagen Stability and Erosion Resistance Through Crosslinking and MMP Inhibition.International journal of nanomedicine · 2024Article
- Evaluation of the efficacy of various remineralization agents and grape seed extract on microhardness and lesion depth of primary tooth enamel: An in vitro study.Journal of dental research, dental clinics, dental prospects · 2024Article
- Dual-functional etchants that simultaneously demineralize and stabilize dentin render collagen resistant to degradation for resin bonding.Dental materials : official publication of the Academy of Dental Materials · 2023Article
- Effect of Different Crosslinkers on Denatured Dentin Collagen's Biostability, MMP Inhibition and Mechanical Properties.Polymers · 2023Article
- The roles of theaflavins in reducing dentin erosion.Scientific reports · 2023Article
- Crosslinking Improve Demineralized Dentin Performance and Synergistically Promote Biomimetic Mineralization by CaP_PILP.ACS omega · 2023Article
- Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding.Materials today. Bio · 2023Article
- Dentin collagen denaturation status assessed by collagen hybridizing peptide and its effect on bio-stabilization of proanthocyanidins.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Evaluation of Proanthocyanidin-based dentifrices on dentin-wear after erosion and dental abrasion -Journal of clinical and experimental dentistry · 2022Article
- Dentin Biomodification with Flavonoids and Calcium Phosphate Ion Clusters to Improve Dentin Bonding Stability.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate whether proanthocyanidins (PA) is capable of improving dentin collagen's biological stability through cross-linking within time periods that are clinically relevant. MATERIALS AND
methodsDemineralized dentin collagen slabs were treated with 3.75 wt% PA solution for 10s, 1 min, 30 min, 60 min, 120 min, 360 min, and 720 min, respectively. The resultant cross-linked collagen samples were subject to digestion with 0.1% collagenase at 37°C for 2h, 6h, 12h, 24h, 36 h, and 48 h. The percentage of weight loss after digestion was calculated to evaluate PA-treated collagen's resistance toward enzymatic degradation. Fourier-transformed infrared (FTIR) spectroscopy was used to probe evidences of PA-collagen interactions after various periods of PA treatment.
resultsThe collagenase digestion assay suggests that PA treatment as short as 10s can enhance collagen's resistance toward enzymatic challenge. The FTIR spectroscopy further verifies that PA is indeed incorporated into collagen regardless of treatment time, possibly via a mechanism involving the chemical interactions between PA and collagen. SIGNIFICANCE: This study confirmed that PA can effectively cross-link collagen and improve its biological stability in time periods as short as 10s. The use of PA as a priming agent is therefore clinically feasible and is a promising approach to improving the durability of current dentin bonding systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.