ArticleGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society2013
Effects of growth hormone treatment in adults with Prader-Willi syndrome.
Article in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Multidimensional Characterisation of Eating Behaviour in Genetic Obesity: A Systematic Review.Obesity facts · 2026Pooled it
- Methods of Determining Energy Expenditure in Individuals with Prader-Willi Syndrome: A Systematic Literature Review.Nutrients · 2024Pooled it
- Growth Hormone Treatment for Adults With Prader-Willi Syndrome: A Meta-Analysis.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Psychotropic treatments in Prader-Willi syndrome: a critical review of published literature.European journal of pediatrics · 2016Pooled it
- Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VOFrontiers in endocrinology · 2026Article
- Bone Health in Adults With Prader-Willi Syndrome: Clinical Recommendations Based on a Multicenter Cohort Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Genetics of Obesity in Humans: A Clinical Review.International journal of molecular sciences · 2022Review
- Molecular Classes and Growth Hormone Treatment Effects on Behavior and Emotion in Patients with Prader-Willi Syndrome.Journal of clinical medicine · 2022Article
- One Year of Recombinant Human Growth Hormone Treatment in Adults with Prader-Willi Syndrome Improves Body Composition, Motor Skills and Brain Functional Activity in the Cerebellum.Journal of clinical medicine · 2022Article
- Management of Prader-Labhart-Willi syndrome in children and in adults, with particular emphasis on the treatment with recombinant human growth hormone.Pediatric endocrinology, diabetes, and metabolism · 2022Review
- Thyroid Function in Adults with Prader-Willi Syndrome; a Cohort Study and Literature Review.Journal of clinical medicine · 2021Article
- One-year follow-up of thyroid function in 23 infants with Prader- Willi syndrome at a single center in China.Intractable & rare diseases research · 2021Article
- Influence of molecular classes and growth hormone treatment on growth and dysmorphology in Prader-Willi syndrome: A multicenter study.Clinical genetics · 2021Article
- Three years of growth hormone treatment in young adults with Prader-Willi syndrome: sustained positive effects on body composition.Orphanet journal of rare diseases · 2020Article
- Article
- Newborn screening for Prader-Willi syndrome is feasible: Early diagnosis for better outcomes.American journal of medical genetics. Part A · 2019Article
- Growth hormone receptor (GHR) gene polymorphism and scoliosis in Prader-Willi syndrome.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2018Article
- Body composition, adipokines, bone mineral density and bone remodeling markers in relation to IGF-1 levels in adults with Prader-Willi syndrome.International journal of pediatric endocrinology · 2018Article
- The neurobiology of the Prader-Willi phenotype of fragile X syndrome.Intractable & rare diseases research · 2016Review
- Growth Charts for Prader-Willi Syndrome During Growth Hormone Treatment.Clinical pediatrics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveSince limited data exist on adults with Prader-Willi syndrome (PWS) and growth hormone (GH) treatment, we report our experience on the effects of treatment for one year on body composition, physical activity, strength and energy expenditure, diet, general chemistry and endocrine data with quality of life measures.
designWe studied 11 adults with PWS (6F:5M; average age=32 yrs) over a 2 year period with GH treatment during the first year only. Electrolytes, IGF-I, glucose, thyroid, insulin, lipids, body composition, physical activity and strength, diet, energy expenditure and quality of life data were collected and analyzed statistically using linear modeling at baseline, at 12 months following GH therapy and at 24 months after treatment cessation for 12 months.
resultsTotal lean muscle mass was significantly increased (p<0.05) during GH treatment along with moderate-vigorous physical activity and plasma IGF-I and HDL levels, but returned to near baseline after treatment. Percent body fat decreased during the 12 months of GH treatment but increased after treatment.
conclusionsPreviously reported beneficial effects of GH treatment in children with PWS were found in our adults regarding body composition, physical activity and plasma HDL and IGF-I levels. Several beneficial effects diminished to near baseline after cessation of GH treatment for 12 months supporting the continuation of treatment in PWS into adulthood and possibly adults not previously treated during childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.