ArticleEuropean journal of neurology2013
Psychosocial risk factors, pre-motor symptoms and first-time hospitalization with Parkinson's disease: a prospective cohort study.
Article in European journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson's Disease.International journal of molecular sciences · 2024Review
- The impact of psychiatric comorbidity on Parkinson's disease outcomes: a systematic review and meta-analysis.The Lancet regional health. Europe · 2024Article
- Early life stress-induced neuroinflammation and neurological disorders: a novel perspective for research.Neural regeneration research · 2022Article
- Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism.International review of neurobiology · 2022Article
- Lipid-lowering drug targets and Parkinson's disease: A sex-specific Mendelian randomization study.Frontiers in neurology · 2022Article
- Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases.JAMA neurology · 2020Article
- NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP.Acta pharmacologica Sinica · 2019Article
- Occupational stress and risk for Parkinson's disease: A nationwide cohort study.Movement disorders : official journal of the Movement Disorder Society · 2018Article
- The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence.Frontiers in neuroscience · 2018Article
- Non-motor features of Parkinson disease.Nature reviews. Neuroscience · 2017Review
- Psychological Stress and Changes of Hypothalamic-Pituitary-Adrenal Axis in Patients with "De Novo" Parkinson's Disease.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Adjustment disorder and risk of Parkinson's disease.European journal of neurology · 2016Article
- Article
- Personality traits and the risk for Parkinson disease: a prospective study.European journal of epidemiology · 2016Article
- Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.Frontiers in aging neuroscience · 2016Review
- Relevance of chronic stress and the two faces of microglia in Parkinson's disease.Frontiers in cellular neuroscience · 2015Review
- Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Frontiers in psychiatry · 2015Review
- Sex differences in Parkinson's disease.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeExperimental studies support a link between stress and development of parkinsonian symptoms, but prospective population studies are lacking. The aim of the current study is to determine the effects of several psychosocial factors on the risk of Parkinson's disease (PD), as well as to identify potential pre-motor symptoms for PD in a large prospective cohort study.
methodsIn 1991-1993, a total of 9955 women and men free of PD from the Copenhagen City Heart Study were asked about major life events, economic hardship, social network, impaired sleep and vital exhaustion. The participants were followed for first-time hospitalization with PD in nationwide registers until 2011.
resultsVital exhaustion was associated with a higher risk of PD hospitalization in an exposure-dependent manner (P(trend) = 0.001), with high vs. low vital exhaustion being associated with a hazard ratio of 2.50 [95% confidence interval (CI): 1.28-4.89]. A slightly higher risk of PD hospitalization (hazard ratio = 1.49; 95% CI: 0.87-2.56) was suggested in participants with impaired sleep at baseline. No more than weak associations were observed for economic hardship, major life events or inadequate social network in the current study.
conclusionsOverall, the hypothesis that psychosocial risk factors affect the risk of PD is not supported. The results, however, suggest that vital exhaustion may be a pre-motor marker of the neurodegenerative process eventually leading to motor symptoms and clinical PD. Vital exhaustion may be useful for screening aimed at early detection and when considering disease-modifying therapies in people at high risk of clinical PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.